近期,美国芝加哥大学医学系的Akash Patnaik研究团队在Clinical Cancer Research杂志上在线发表了题为“Reversal of lactate and PD-1-mediated macrophage immunosuppression controls growth of PTEN/p53-deficient prostate cancer”的研究论文...
[6]Na Kong et al. Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition. Science Translational Medicine(2019). $罗氏控股(RHHBY)$$恒瑞医药(SH600276)$$复星医药(SH600196)$
[6]Na Kong et al. Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition. Science Translational Medicine(2019).
27. Kong N, Tao W, Ling X, et al. Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition.Sci Transl Med. 2019;11(523):eaaw1565. doi:10.1126/scitranslmed.aaw1565
3. Feeley KP, Adams CM, Mitra R, Eischen CM. Mdm2 Is Required for Survival and Growth of p53-Deficient Cancer Cells. Cancer Res 2017;77(14):3823-33 doi 10.1158/0008-5472.CAN-17-0809.4. Nalawansha DA, Crews CM. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell ...
1、《Deficient or R273H and R248W Mutations of p53 Promote Chemoresistance to 5-FU via TCF21/CD44 Axis-Mediated Enhanced Stemness in Colorectal Carcinoma》 Two HCT116 cell lines containing hot spots at codons R273H and R248W of ...
al. Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient ...
these mutants often have gain-of-function activity and contribute to the malignant properties of cancer cells [6]. For instance, Dittmer et al. introduced p53 V143A, R175H, R248W, R273H, and D281G mutants into p53-deficient fibroblasts, resulting in enhanced tumorigenic potential in nude mi...
2n). Nevertheless, a significant increase in 13C-asparagine was found in p53-deficient cells (Fig. 2o). To verify the cell culture findings in animals, we compared the asparagine levels in tissues from p53+/+ mice and p53−/− mice. Consistent with the plasma data (Fig. 1c, ...
Prolonged survival of heart allografts from p53-deficient mice Hu Y,Zou Y,Hala M,Dietrich H,Wick G,Xu Q.Prolonged survival of heart allografts from p53-deficient mice. Transplantation . 2000... Y Hu,Y Zou,M Hala,... - 《Transplantation》 被引量: 23发表: 2000年 Survival Of Mhc-...