Venkatachalam, S., Tyner, S., and Donehower, L. A. (2001) The p53-deficient mouse as a cancer model, in Tumor Models in Cancer Research (Teicher, B.A., ed.). Humana Press, Totowa, NJ 247–261.Venkatachalam, S., Tyner, S., Donehower, L. A. The p53-deficient mouse as a ...
Mao Jiahui,Liang Zhaofeng,Zhang Bin,etc.UBR2 Enriched in p53 Deficient Mouse Bone Marrow Mesenchymal Stem Cell-Exosome Promoted Gastric Cancer Progression via Wnt/β-Catenin Pathway[J].2017,35(11).MAO J, LIANG Z, ZHANG B, et al. UBR2 Enriched in P53 -/- mBMMSC-Exosome promoted gastric...
Herein, we describe a mouse model of heart allografts donated by p53-/- mice that can prolong the survival time of the grafts. METHODS: Hearts of p53-/- or p53+/+ C57BL/6J mice were grafted to the neck carotid artery and jugular vein of BALB/c mice using a cuff technique. The ...
Cisplatin could also induce typical apoptosis in p53-deficient baby mouse kidney (BMK) cells. The apoptosis was caspase dependent and could be completely blocked by general caspase inhibitors. Bax and Bak, two key molecules in the mitochondrial pathway of apoptosis, were interdependently activated by...
Because of its reactivity with different specific anti-p53 antibodies, we have determined that the p53 protein present in PARP knockout mouse cells possesses characteristic features of AS p53. Our results clearly show that PARP-deficient cells constitutively express the AS form of wt p53 and ...
Simvastatin enhances the radiosensitivity of p53‑deficient cells via inhibition of mouse double minute 2 homologdoi:10.3892/ijo.2017.4192simvastatin... L Ji,MS Kim,J Ju,... - 《International Journal of Oncology》 被引量: 0发表: 2017年 Simvastatin enhances the radiosensitivity of p53‑deficient...
(v) A thin layer of leukemic cells is seen in the subarachnoid space of a DM mouse that did not have any neurological signs. This mouse, representative of 48% (11/23) of this genotype, had scanty subarachnoid cellular infiltrate but no signs of neurological impairment. (vi) Extensive lepto...
493Citations 21Altmetric Metrics Abstract Defects in neural tube formation are among the most common malformations leading to infant mortality. Although numerous genetic loci appear to contribute to the defects observed in humans and in animal model systems, few of the genes involved have been charact...
The growing tumor in the lung showed a high level expression of TIAF1 as compared with the normal lung of a nude mouse. Scale bar, 200 mm; Â 400 magnification (IHC). A representative data set is shown from three repeats Also, petri dishes were coated with various amounts of matrix ...
Here we show that conditional inactivation of Trp53 in the mouse prostate fails to produce a tumour phenotype, whereas complete Pten inactivation in the prostate triggers non-lethal invasive prostate cancer after long latency. Strikingly, combined inactivation of Pten and Trp53 elicits invasive ...