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抗体来源 : Mouse *类型 : Monoclonal 克隆号 : 15F6 交叉反应 : Human, 产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be...
The p53 tumor suppressor protein plays an important role in regulating the cellular response to DNA damage, including cell cycle arrest and apoptosis induction. Normal p53 function is critical for the maintenance of genomic stability. The mouse lymphoma L5178Y/TK+/−-3.7.2C cell line is widely...
Consistent with our studies in mouse PDAC lines, knockdown of either mutant p53 or PDGFRb reduced invasiveness of the A2.1 pancreatic cancer cell line (Figure 3E). Conversely, overexpression of PDGFRb in the human p53−/− ASPC pancreatic cancer cell line enhanced invasion compared to cells ...
Moreover, the inhibition of tumor growth by inducing p53/SIRT6/PARP1-dependent parthanatos was further verified in the xenograft mouse model. Results For the first time, we identified that inhibiting AKT triggered parthanatos, a new form of regulated cell death, leading to colon cancer growth ...
交叉反应Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep 产品类型一抗 研究领域信号转导 细胞凋亡 蛋白分子量predicted molecular weight: 53kDa 性状Lyophilized or Liquid 免疫原KLH conjugated synthetic peptide derived from human P53 C-terminus ...
(+) T cell infiltration and activation, while single copy loss of HIF1α or high levels of HIF2α mRNA expression correlate with altered immune microenvironments in human ccRCC [72]. However, researchers may want to keep in mind that mouse ccRCC tumor models may not always fully reflect ...