What is p53? What is pRB? How are they involved in cancer? What are their pathways and why do cancer cells need to lose both P53 and pRB? How might the disruption of the cell cycle lead to cancer? What are the risk factors of brain tumors?
Cell biology is the study of a cell as an individual unit, exploring physiological processes and mechanisms that allow life processes to operate at the molecular level, including cellular structure, division, energy exchange, signaling pathways, and more. Cell biology research studies many cell types...
Why are cancer cells or abnormal cells used in tissue cultures even when researchers are not studying cancer? Briefly explain how a cancer cell differs from a normal cell. What is p53? What is pRB? How are they involved in cancer? What are their pathways and why do c...
Cell 92, 401–413 (1998).This report demonstrates that deprotection of telomeres by inhibiting the function of human TRF2 leads to chromosome fusions. CAS PubMed Google Scholar Fumagalli, M. et al. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat. ...
Cellular senescence is a state of stable cell cycle arrest. Cells remain metabolically active, but no longer divide or respond to growth-promoting stimuli.
Metabolic reprogramming is a pivotal biological process in which cellular metabolic patterns change to meet the energy demands of increased cell growth and proliferation. In this review, we explore metabolic reprogramming and its impact on fibrotic disea
The p53 pathway is composed of hundreds of genes and their products that respond to a wide variety of stress signals. These responses to stress include apoptosis, cellular senescence or cell cycle arrest. In addition the p53-regulated genes produce prote
Small-cell lung cancer (SCLC) is a deadly cancer associated with smoke exposure that has neuroendocrine (NE) cell properties and is pathologically, molecularly, biologically and clinically very different from other lung cancers. While most patients with SCLC respond initially to cytotoxic therapy, almo...
Andrographolide (AG) is a labdane diterpenoid isolated from Andrographis paniculata, known for its antimicrobial, anti-inflammatory, anticancer, neur..
Cell division is an essential process that takes place in every living cell. This process involves the division of a parent cell into two daughter cells. These daughter cells are structurally or genetically similar to the parent cell. There are two types of cell division that is mitosis and ...