The complex process of cell immortalization and transformation is likely to involve the inactivation of growth regulatory genes. Mutations (deletions, missense mutations) in the p53 gene are the most frequently observed genetic alteration in human tumors, making p53 a candidate for a cellular protein ...
What sperm count is considered to be infertile? What is p53? What is pRB? How are they involved in cancer? What are their pathways and why do cancer cells need to lose both P53 and pRB? What factors cause a cell to age? What is a test males should get annually after the age of ...
Cell division is necessary so that the genetic material is passed on to the next generation, the growth of the cells, and for various other reasons.Answer and Explanation: Mitosis is a type of cell division that is known for the equational division of the cell in which a single parent cell...
Carboplatin is a second-generation platinum compound analog with established activity against a broad spectrum of solid tumors including brain tumors, neuroblastoma, rhabdomyosarcoma, and germ cell tumors. It is commonly used for pediatric cancer and approximately one-third of children with solid tumor ...
Implicit in optimal loading is the need to monitor the response to load, but what constitutes a normal response to loading? And does it differ among tissues (e.g., muscle, tendon, bone, cartilage) and systems? In this paper, we discuss the “normal” tissue response to loading schema ...
Cell 92, 401–413 (1998).This report demonstrates that deprotection of telomeres by inhibiting the function of human TRF2 leads to chromosome fusions. CAS PubMed Google Scholar Fumagalli, M. et al. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat. ...
更新1: richardhong18: Thank you for your wer Downs syndrome is NOT hereditary. Patients with Downs their parents can be normal.更新2: ln3053ah: 请问你的资料可否注明出处？ Li-Fraumeni syndrome: p35? 不是 p53 吗?The following diseases can be inherited. Common cancers:[gene ...
p53—INTEGRATING THE COMPLEXITY Calvert, RJ, Evans, PA, Randerson, JA (1996) The significance of B-cell clonality in gastric lymphoid infiltrates. J Pathol 180: pp. 26-32Hall, P... HALL, PETER A.,MEEK, DAVID,LANE, DAVID P. - 《Journal of Pathology》 被引量: 233发表: 1996年 ...
A growing number of p53 responsive genes have been identified and numerous studies have demonstrated that p53 proapoptotic factors such as Noxa, Puma and Perp play cell type specific roles in p53's mediated response to certain stimuli. Perp (p53 apoptosis effector related to PMP-22) is a ...
Metabolic reprogramming is a pivotal biological process in which cellular metabolic patterns change to meet the energy demands of increased cell growth and proliferation. In this review, we explore metabolic reprogramming and its impact on fibrotic disea