8. Jiandong Chen, et al. The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression. Cold Spring Harb Perspect Med. 2016 Mar 1;6(3):a026104. 9. Alexei Vazquez, Gareth L Bond, et al. The genetics of the p53...
8. Jiandong Chen, et al. The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression. Cold Spring Harb Perspect Med. 2016 Mar 1;6(3):a026104.9. Alexei Vazquez, Gareth L Bond, et al. The genetics of the p53 pathway, apoptosis and cancer therapy. Nat Rev ...
While caspase-2 is implicated in many cell death and non-cell death functions30, here, we discuss recent data that link caspase-2 to p53 stability and its various functions, including cell cycle regulation and tumor suppression. Fig. 2: Caspase-2 structure and activation. In the primary ...
[5] Li B, Cheng Q, Li Z, et al. p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors[J]. Cell Cycle, 2010, 9(7): 1411-1420. [6] Traweek RS, Cope BM, Roland CL, Keung EZ, ...
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12. Tsao CC, Corn PG. MDM-2 antagonists induce p53-dependent cell cycle arrest but not cell death in renal cancer cell lines.Cancer Biol Ther. 2010;10(12):1315-1325. doi:10.4161/cbt.10.12.13612 13. Jeay S, Gaulis S, Ferretti S, et al. A distinct p53 target gene set predicts for...
近日,哥伦比亚大学医学中心顾伟教授及其博士后刘彦卿博士在Cell Death & Differentiation期刊发表了题为: p53 in ferroptosis regulation: the new weapon for the old guardian 的综述论文。该综述全面梳理总结了p53在铁死亡调节中的复杂作用。 2012年以前,学界认为p53的诱导细胞周期停滞,衰老或者凋亡(cell cycle arrest, ...
Cell Cycle, 2011, 10(2): 301-307.38. Wiman K G. Restoration of WildType p53 Function in Human Tumors: Strategies for Efficient Cancer TherapyJ. 48、Advances in cancer research, 2007, 97: 321-338.39. Armata H L, Garlick D S, Sluss H K. The Ataxia TelangiectasiaMutated Target Site ...
The functional spectrum of these pathway targets spans from the G1 phase to the end of mitosis. Consequently, through downregulating the expression of gene products which are essential for progression through the cell cycle, the p53–DREAM pathway participates in the control of all checkpoints from...
Corn PG. MDM-2 antagonists induce p53-dependent cell cycle arrest but not cell death in renal c...