有时,黑化到极致的p53基因还会获得功能性突变(gain-of-function mutation),华丽丽地变身为一个“癌基因”,从多个角度给癌症的发生发展添buff,如增强肿瘤的侵袭性和耐药性等。虽然这些获得功能性突变可以有多种活性,但是最主要的规律是这些突变会对抗野生型p53的功能,或者加重p53缺失造成的结果。 能者多劳,庞大的p53...
[7] Zhou X,Hao Q,Lu H. Mutant p53 in cancer therapy-the barrier or the path[J]. J Mol Cell Biol,2019,11(4):293-305. [8] Liao P,Zeng S X,Zhou X,et al. Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding[J...
Cell 137, 413–431 (2009). Article CAS PubMed Google Scholar Petitjean, A. et al. Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Hum. Mutat. 28, 622–629 (2007). Article CAS PubMed ...
p53 mutation of each cell line as indicated. p53 and actin levels were determined by western blotting (lower panel). (E) Quantification of invasion of human A2.1 cells infected with sh.PDGFRb, sh.p53, or sh.Ctrl (right). Data presented as mean ± SD. ∗∗p < 0.005, ∗∗∗p...
of Y220C Mutant p53, in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation. ...
same tumor on the same p53 allele: MM (Multiple Mutation): More than two p53 mutations in the same tumor. Name Name of the tumor/patient/cell line as given by the authors. If the publication does not include any sample name, we have arbitrarily assigned a name, usually the first ...
cell cycle arrest and apoptosis, whereas p53 R175P mutant induces only cell cycle arrest and p53 R175D mutant loses both functions [3,33]. In addition,TP53mutation will increase structural instability and expose adhesion sequence wrapped in the hydrophobic core of p53 to protein surface, which ...
A CML blast crisis cell line, JOSK-M, was reported to have the same splice junction mutation in the p53 gene as U937.28 These intronic point mutations appear to inactivate the normal splicing junction and alter the p53 mRNA processing. Takahashi et al reported that two lung cancer cell ...
抑制基因抗体(野生型P53)说明书NA Others H1N1 甲型 H1N1 (A/California/04/2009) 神经氨酸酶 (Neuraminidase / NA) (N295S mutation) 人细胞裂解液 (阳性对照) CL-0218SPC-A-1(人细胞)5×106cells/瓶×2 人真皮成纤维细胞-cDNAHDF-a cDNA
Mutant p53 has different structures compared with wild-type p53, which causes colon cancer cell progression and promotes tumor metastasis. Here, we showed that the PHLPP2-AKT pathway is a major target by which p53 promotes malignancy. In this research, we found p53 mutation could bind the ...