Germline mutations of p53 gene are rare, worldwide there are reported about 283 of such changes. They are strongly connected with Li-Fraumeni and Li-Fraumeni Like syndromes. They also may appear in multicancer s...
Lack of mutations in the P53 gene exons 5 to 8 in ataxia-telangiectasia 1993, Cancer Genetics and Cytogenetics more Philippe Jonveaux, Roland Berger Lack of mutations in the P53 gene exons 5 to 8 in ataxia-telangiectasia Cancer Genetics and Cytogenetics, Volume 66, Issue 2, April 1993, Pag...
p53 gene mutations in gastric adenomas p53 gene alterations in ten gastric adenomas and one carcinoma arising in an adenoma were analyzed by deoxynucleotide sequencing. Three (30%) of the ten ga... H Tohdo,H Yokozaki,K Haruma,... - 《Virchows Archiv B》 被引量: 178发表: 1993年 ...
Mutations of the p53 suppressor gene are involved in carcinogenesis by inactivating p53 protein (p53P), which is involved in normal cell growth control. Mutant p53P, detectable by immunohistochemistry due to longer half-life as compared to wild-type, is a marker for p53 gene mutation. Seventy-...
Tricker KJ, Prosser J, Condie A, Kelsey AM, Harris M, Morris Jones PH, Binchy A, Crowther D, Craft AW, Eden OB, Evans GR, Thompson E, Mann JR, Martin J, Mitchell ELD, Santibáñez-Koref MF: Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni ...
In the same experiments, however, all known exon mutations as well as previously unreported mutations in the intron sequences of the p53 and Rb genes in the HPV-free C33-A and HT-3 cell lines were detected. The absence of mutation in the p53 gene in all five HPV-negative samples was ...
Medical Center for Postgraduate Education, and Maria Skodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland Comparison of immunohistochemical methods for detection of protein p53 accumulation and molecu- lar techniques for analysis p53 gene mutation in col- orectal cancer is ...
We report here the molecular cloning and sequencing of the p53 gene from HOS-SL cells, and demonstrate that it is in fact mutant. Further, analysis of similar HOS-derived cell lines demonstrates that they also encode the same mutant form of p53, whereas the wild type form of p53 appears ...
Inactivation of the p53 gene by either mutation or HPV infection is extremely frequent in human oral squamous cell car- cinoma cell lines. Eur J Cancer B Oral Oncol 1994; 30B(5): 338- 45.Min BM, Baek JH, Shin KH, Gujuluva CN, Cherrick HM, Park NH. Inactivation of the p53 gene ...
摘要: Aflatoxinsufererandp53genemutationinhepatocelularcarcinoma DENGZhuo LinandMAYunSubjectheadingsAflatoxinB1;genes,p53;mutation;...关键词:? AFLATOXIN B1 genes p53 MUTATION carcinoma HEPATOCELLULAR liver NEOPLASMS DOI: 10.3748/wjg.v4.i1.28 被引量: 165 ...