Soussi T, Lozano G (2005) p53 mutation heterogeneity in cancer. Biochem Biophys Res Commun 331: 834–842Soussi T, Lozano G. p53 mutation heterogeneity in cancer. Biochem Biophys Res Commun. 2005;331:834–42.Soussi T, Lozano G: p53 mutation heterogeneity in cancer. Biochem Biophys Res Commun...
4.Silwal-Pandit L, Vollan HK, Chin SF, Rueda OM, McKinney S, Osako T, Quigley DA, Kristensen VN, Aparicio S, Børresen-Dale AL, Caldas C, Langerød A. TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance. Clin Cancer Res. 2014 Jul 1;20...
4.Silwal-Pandit L, Vollan HK, Chin SF, Rueda OM, McKinney S, Osako T, Quigley DA, Kristensen VN, Aparicio S, Børresen-Dale AL, Caldas C, Langerød A. TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance. Clin Cancer Res. 2014 Jul 1;20...
Evidence suggests that theTP53mutational spectrum differs between tumors [38,39]. The cBioportal for Cancer Genomics Database (https://www.cbioportal.org/) showed that frequency ofTP53mutations in tumor tissue samples from 10,000 cancer patients is 42%. However, the mutation frequency varies acro...
Gaurav Mendiratta 等人在 2021 年发表的“Cancer gene mutation frequencies for the U.S. population” 中,通过结合基因组 (所有癌症中每个基因中包含一个或多个突变的估计比例) 和流行病学数据也统计了美国人群中基因突变的频率,发现TP53是最常见的突变基因 (35...
Gaurav Mendiratta 等人在 2021 年发表的“Cancer gene mutation frequencies for the U.S. population” 中,通过结合基因组 (所有癌症中每个基因中包含一个或多个突变的估计比例) 和流行病学数据也统计了美国人群中基因突变的频率,发现 TP53 是最常见的突变基因 (35%)。
Gaurav Mendiratta 等人在 2021 年发表的“Cancer gene mutation frequencies for the U.S. population” 中,通过结合基因组 (所有癌症中每个基因中包含一个或多个突变的估计比例) 和流行病学数据也统计了美国人群中基因突变的频率,发现 TP53 是最常见的突变基因 (35%)。
& Xu, Y. p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM. Nat. Cell Biol. 9, 573–580 (2007). Article CAS PubMed Google Scholar Solomon, H. et al. Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene ...
[15].Donehower L A, Soussi T, Korkut A, et al. Integrated analysis of TP53 gene and pathway alterations in the cancer genome atlas[J]. Cell reports, 2019, 28(5): 1370-1384. e5. 本文作者 | BioTalker 越来越接近真相
p53 mutations were associated with invasive ductal carcinoma, large tumor size, and advanced disease stagep53 gene mutations is potentially responsible for pathogenesis and clinical aggressiveness of breast cancer in our locality. 展开 关键词: mutations breast cancer p53 ...