39]. The cBioportal for Cancer Genomics Database (https://www.cbioportal.org/) showed that frequency ofTP53mutations in tumor tissue samples from 10,000 cancer patients is 42%. However, the mutation frequency varies across different types of tumors, with mutation frequency of 89.02% in small c...
Hence the particular TP53 mutation, not just the presence or absence of TP53 mutations, may be of future value when devising individualized treatment strategies for CRC, and most probably also for other cancer types. Surprisingly, in our study p53R175H did not exert measurable effects on the ...
Within the last decades this region has been characterized by the highest incidence of lung cancer in Poland. We used both frozen and paraffin-embedded tumor samples and the screened region included exons from 5 to 8. A total of 96 samples (29%) were positive for p53 gene mutation. The ...
Inflammatory Bowel Disease and Colon Cancer Hussain SP, Amstad P, Raja K et al (2000) Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease. Cancer Res 60:3333–3337PubMed Imielinski M, Baldassano RN, ... N Jawad,N ...
P-023. Angiogenesis and p53 mutation in oral squamous cell carcinoma Aims: Despite the adequate therapy, there is a subset of patients with early stage oral squamous cell carcinoma, such as tongue cancer, who may have unpred... MS Kim,DI Sun,KJ Cho,... 被引量: 0发表: 2001年 加载更多...
The TP53 mutation frequency is higher in node-positive breast cancer [4]. In addition, some studies have claimed a prognostic and or predictive value for TP53 in relation to different cytotoxic agents and tamoxifen [5., 6., 7., 8.], while other studies have failed to demonstrate such ...
p53 mutation remains the most common genetic change identified in human neoplasia. In breast cancer, p53 mutation is associated with more aggressive disease and worse overall survival. The frequency of mutation in p53 is, however, lower in breast cancer than in other solid tumours. Changes, both...
2024年是p53蛋白被发现45周年。为庆祝这一事件,2024年5月9日,美国哥伦比亚大学欧文医学中心顾伟教授课题组(刘彦卿博士为第一作者)应邀在Cancer Cell杂志撰写了题为:Understanding the complexity of p53 in a new era of tumor suppression的长文综述...
The tumour suppressor gene TP53 is the most frequently mutated gene in cancer. Wild-type p53 can suppress tumour development by multiple pathways. However, mutation of TP53 and the resultant inactivation of p53 allow evasion of tumour cell death and rapid tumour progression. The high frequency of...
may influence NSCLC responsiveness to EGFR inhibition in patients harboringEGFRmutations57,58. The Lung Cancer Mutation Consortium (LCMC) has also reported thatTP53mutations are the most commonly occurring event together withEGFRmutations59. However, mis-sense mutations in the TAD were categorized as ...