4.Silwal-Pandit L, Vollan HK, Chin SF, Rueda OM, McKinney S, Osako T, Quigley DA, Kristensen VN, Aparicio S, Børresen-Dale AL, Caldas C, Langerød A. TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance. Clin Cancer Res. 2014 Jul 1;20...
Cancer Lett 2005;218:69-79.Katiyar S, Hedau S, Jain N, Kar P, Khuroo MS, Mohanta J, Kumar S, Gopalkrishna V, Kumar N, Das BC. p53 gene mutation and human papillomavirus (HPV) infection in esophageal carcinoma from three different endemic geographic regions of India. Cancer Lett. ...
分类号VDC八年制毕业论文密级p53基因突变与乳腺癌新辅助化疗疗效关系的研究Therelationshipbetweenp53genemutationandbreastcancerneoadjuvantchemotherapyefficiency作者姓名:***科专业:外科学(乳腺外科)院、系(所):湘雅医院指导教师:**立教授论文答辩日期垒学答辩委员会主席√么型7中南大学二0一二年五月 原创...
which encode the DNA binding domain, with the most common mutation sites occurring at R175, G245, R248, R249, R273 and R282 (Fig.1c). Using the COSMIC Database (https://cancer.sanger.ac.uk/signatures/) showed that the most substitution mutations are G to ...
The tumour suppressor gene TP53 is the most frequently mutated gene in cancer. Wild-type p53 can suppress tumour development by multiple pathways. However, mutation of TP53 and the resultant inactivation of p53 allow evasion of tumour cell death and rapid tumour progression. The high frequency of...
"A Li-Fraumeni syndrome family with retained heterozygosity for a germline TP53 mutation in two tumors." Cancer Genetics and Cytogenetics 145.1(2003):60-64. 19.Kastan, Michael B , and E. Berkovich . "p53: a two-faced cancer gene. " Nature Cell Biology 9.5(2007):489-91. 20.Eliyahu D...
Noel JC, Heenen M. Posttransplant skin cancer: a possible role for p53 gene mutation but not for oncogenic human papillomaviruses. J Am Acad Dermatol 1995;32:819-20.Noel J-C, Heenen M. Posttransplant skin cancer: a possible role for p53 gene mutation but not for oncogenic human pa...
p53基因是一种肿瘤抑制基因(tumor suppressor gene),是最早发现的抑癌基因之一。该基因编码一种分子量为43.7KDa的蛋白质,但因蛋白条带出现在Marker所示53KDa处,命名为P53。p53肿瘤抑制基因位于17号染色体上,并且编码393个氨基酸蛋白。p53基因突变是人类癌症中zui常见的特异性基因突变之一,是DNA损伤和其他细胞代谢(包括...
Conclusion: Mutations of p53 occur commonly in human o-varian cancer. p53 mutation is an early event in ovarian carcinogenesis and may serve as a geneticmarker for early diagnosis and prognosis .Key words Ovarian neoplasms suppressor Genes, p53 Mutation Exons p53基因突变已被发现是与人类恶性肿瘤有...
As a remark, that mutations of p53 and c-myc are found 50% in cancer. Objective: Aims of this research were to know the relationship between the mouth squamous cell carcinoma (MSCC) with HPV infection, the presence of p53, and c-myc genes mutation. Methods and Material: Tissue biopsy ...