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The chapter also accounts for p53 mutations in sporadic cancers focussing on host-environment interactions. The chapter concludes with the potential clinical applications of the detection of p53 mutations in human tissues.Access through your organization Check access to the full text by signing in ...
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TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often acquires inherent, novel oncogenic functions, which is termed “gain-of-function”. Emerging evidence suggests that mutp53 is h...
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The tumor suppressor protein p53 loses its function in more than 50% of human malignant tumors. Recent studies have suggested that mutant p53 can form aggregates that are related to loss-of-function effects, negative dominance and gain-of-function effects and cancers with a worsened prognosis. ...
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