In colorectal cancers, the smallest common region of deletion is centred at 17pl3.1 (ref. 9); this region harbours the p53 gene and in two tumours examined in detail, the remaining (non-deleted) p53 alleles were found to contain mutations 9 . This result was provocative because allelic ...
S. Deep generative models of genetic variation capture the effects of mutations. Nat. Methods 15, 816–822 (2018). Article CAS PubMed PubMed Central Google Scholar Sevgen, E. et al. ProT-VAE: Protein Transformer Variational AutoEncoder for functional protein design. Preprint at bioRxiv ...
A mutation changes the genetic material (genome) of a live organism's cell or a virus. Mutations can occur due to errors in DNA's regular chemical transactions, such as replication or as a result of exposure to high-energy electromagnetic radiation (ultraviolet light or X-rays), particle rad...
S. Deep generative models of genetic variation capture the effects of mutations. Nat. Methods 15, 816–822 (2018). Article CAS PubMed PubMed Central Google Scholar Sevgen, E. et al. ProT-VAE: Protein Transformer Variational AutoEncoder for functional protein design. Preprint at bioRxiv ...
p53 loss of heterozygosity (p53LOH) is frequently observed in Li-Fraumeni syndrome (LFS) patients who carry a mutant (Mut) p53 germ-line mutation. Here, we focused on elucidating the link between p53LOH and tumor development in stem cells (SCs). Although
ING4 contains the potential BP NLS 128KGKKGRTQKEKKAARARSKGKN149, among which 142RARSK146 mainly binds to p53 and mediates the nuclear localization of ING4 and p53 [23]. The interaction of ING4 with p53 was abrogated in vitro and in vivo when certain mutations or deletion of the entire ...
Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. Two types of murine helper T cell clones Mutations in the p53 gene occur in diverse human tumour types THE CORRELATES OF ENTREPRENEURSHIP IN THREE TYPES OF FIRMS...
A G to T mutation has been observed at the third position of codon 249 of the p53 tumor-suppressor gene in over 50/100 of the hepa- tocellular carcinoma cases associated with high exposure to afla- toxin B_1 (AFB_1). Hypotheses have been put forth that AFB_1, in concert with hepati...
(deletions, translocations and mutations) inPAX5occur in approximately 30% of sporadic cases9. Whereas mostPAX5somatic missense mutations affect the DNA-binding domain (V26G or P80R), G183S is a recurrent familial germline mutation that confers an elevated risk of developing B-ALL8,9,10. ...
An auxin-based degron system for the rapid depletion of proteins in nonplant cells. Nat. Methods 6, 917–922 (2009). Article CAS PubMed Google Scholar Watanabe, Y. et al. Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer. PLoS ONE 6, e23320 (...