Brentnall TA, Crispin DA, Rabinovitch PS, Haggitt RC, Rubin CE, Stevens AC, Burmer GC. Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis. Gastroen- terology 1994;107:369-378.Brentnall TA, Crispin DA, Rabinovitch PS, Haggitt RC, Rubin CE, Stevens ...
In colorectal cancers, the smallest common region of deletion is centred at 17pl3.1 (ref. 9); this region harbours the p53 gene and in two tumours examined in detail, the remaining (non-deleted) p53 alleles were found to contain mutations 9 . This result was provocative because allelic ...
As PCR-SSCP analysis is a convenient method to detect point mutation, we have now examined 24 colorectal cancers for the p53 gene by this method, and detected the mutations. Furthermore, expression of the DCC gene, a candidate of tumor suppressor gene involved in colorectal carcinogenesis, was...
AIMS: To attempt to detect p53 gene mutations in the plasma of patients with large bowel carcinoma. METHODS: Plasma was collected from 20 control patients with no history of cancer and from 17 patients with large bowel carcinoma. Corresponding tumour and benign lymph node (control) samples for ...
[47,48]. LFS is described by the heterozygous germline mutations in theTP53gene [49]. Family history of inherited mutant (pathogenic variant)TP53is a key criterion for the consideration of LFS yet, de novo mutations occur in∼10%–20% of LFS cases [50]. Recent whole-genome sequence ...
These studies have identified a region between amino acids 132 and 215 in the p53 protein which, when mutated, can activate the p53 cDNA. These results also call into question what the correct p53 wild-type sequence is and whether a wild-type p53 gene can transform cells in culture. 展开 ...
Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to ...
We screened 77 non-small-cell lung cancer (NSCLC) cell lines for mutations of the p53 gene using a single-strand conformation polymorphism (SSCP) assay. We... T Mitsudomi,SM Steinberg,MM Nau,... - 《Oncogene》 被引量: 1480发表: 1992年 Implications of the p53 tumor-suppressor gene in ...
We used the cre-lox system to delete p53 in AgRP, POMC, or SF-1 neurons. p53loxP/loxPmice were purchased from The Jackson Laboratory (B6; 129S4 Trp53tm5Tyj/J). To investigate the role of AgRP, POMC, or SF-1-expressing neurons, we inactivated the p53 gene specifically in each of t...
The TP53 gene is frequently mutated in human cancer. Research has focused predominantly on six major “hotspot” codons, which account for only ∼30% of cancer-associated p53 mutations. To comprehensively characterize the consequences of the p53 mutation spectrum, we created a synthetically designed...