表明p53蛋白主要分布在细胞核中.使用PRABI-GERLAND算法对p53二级结构进行预测,结果表明18.07%为α螺旋,18.07%为β折叠,63.87%为无规则卷曲.最后,采用同源建模(比较建模)方法构建了p53蛋白的三级结构,从建模质量评估表明预测结果准确.%p53, as a key tumor suppressor protein, is involved in the occurrence of more...
Reports that scientists have determined the three-dimensional structure of a regulatory protein region on the p53 protein's amino terminus, showing how the amino acids that form it fold up and link to another protein called MDM2. Research by Pavletich et al. on page 948 of the November 8, ...
The comprehensive function of p53 is closely related to its modular structure of typical signaling proteins.201Human p53 is a multidomain protein that consists of 393 amino acids.259It contains an N-terminal transactivation domain (TAD, residues 1–61), a proline-rich domain (PRD, residues 64...
DimensionalStructureandBiologicalDomainsofthep53C-terminus.ZHANGYan(KunmingMedicalCollege.Kunming650031,China);LIUCi-Quan(KunmingInstituteofZoology,TheChineseAcademyofSciences.Kunming650223,China).Abstract Itwasexpectedthatthereareacoil(289～325)andtwoαhelix(α1368～373,α2381～388)structuresinp53proteinC-...
被称为金属伴侣(metallochaperons)的药物能够帮助展开的蛋白(unfolded protein)与锌离子结合并且形成一个较为正常的构像,从而恢复与DNA结合的能力。而另一种策略利用了一个意想不到的发现,那就是有些p53突变蛋白有形成像淀粉样蛋白一样的聚合物的倾向,当聚合过程被扰乱后,p53的功能可以得到恢复并且在异种移植模型中...
被称为金属伴侣(metallochaperons)的药物能够帮助展开的蛋白(unfolded protein)与锌离子结合并且形成一个较为正常的构像,从而恢复与DNA结合的能力。而另一种策略利用了一个意想不到的发现,那就是有些p53突变蛋白有形成像淀粉样蛋白一样的聚合物的倾向,当聚合过程被扰乱后,p53的功能可以得到恢复并且在异种移植模型中...
Pharmacological reactivation of mutant p53: from protein structure to the cancer patient 来自 Nature 喜欢 0 阅读量: 76 作者:Wiman,K G 摘要: The p53 tumor suppressor pathway blocks tumor development by triggering apoptosis or cellular senescence in response to oncogenic stress. A large fraction of ...
The structure formed by inverted repeats in p53 response elements determines the transactivation activity of p53 protein 来自 国家科技图书文献中心 喜欢 0 阅读量: 16 作者:V Brázda,?echová, Jana,M Battistin,J Coufal,EB Jagelská,I Raimondi,A Inga ...
Structure-based mutations at the interface impair the p53/BCL-2 interaction. Specifically, the binding sites for p53 and the pro-apoptotic protein Bax in the BCL-2 pocket are mostly identical. In addition, formation of the p53/BCL-2 complex is negatively correlated with the formation of BCL-...
然而，PPI（protein-protein interaction）抑制剂的开发是很困难的一件事情。小分子难以结合在两个蛋白之间...