1.《Drugging p53 in cancer: one protein, many targets》, 2022, Nature Reviews Drug Discovery 2.《p53 signaling in cancer progression and therapy》, 2021, BMC 3.《Heterogeneity of TP53 Mutations and P53 Protein Residual Function in Cancer: Does It Matter?》, 2020, Frontiers in Oncology 4.《...
降解机制为通过E3泛素连接酶MDM2对p53的泛素化,导致p53被蛋白酶体降解。此泛素化过程依赖于MDM2和p53的直接结合,因此开发MDM2抑制剂,阻断MDM2-p53 PPI (protein-protein interaction)作用成为主流策略。RG7112、APG-115、AMG-232等MDM2纷纷进入临床,但最大的挑战是获得性耐药和由于p53分布广泛性而带来的毒性。目前对这...
Rac1gain of functiontumorigenesisTumor suppressor p53 is the most frequently mutated gene in human cancer. Mutant p53 (mutp53) not only loses the tumor suppressive activity of wild type p53, but often gains new oncogenic activities to promote tumorigenesis, defined as mutp53 gain of function (...
p53这个靶点吸引了赛诺菲（Sanofi）和默克（Merck）等竞争对手，重新激发了大家对蛋白-蛋白相互作用（protei...
然而，PPI（protein-protein interaction）抑制剂的开发是很困难的一件事情。小分子难以结合在两个蛋白之间...
Here, we demonstrate that gain-of-function (GOF) p53 protein can be packaged into small EVs and transferred to fibroblasts. GOF p53 protein is selectively bound by heat shock protein 90 (HSP90), a chaperone protein, and packaged into small EVs. Inhibition of HSP90 activity blocks packaging ...
As p53 is such a potent inhibitor of cell growth, its function must be tightly controlled to allow normal growth development. This is achieved through several mechanisms that include regulation of p53 transcription and translation, protein stability, subcellular localization and activity [19]. Rapid ...
英文名称Anti-P53 protein(wt-p53) 中文名称抑制基因P53蛋白抗体(野生型P53)费用 别名Widespread p53; Wtp53; Antigen NY-CO-13; Cellular tumor antigen p53; Cys 51 Stop; HGNC11998; LFS1; p53; p53 Cellular Tumor Antigen; p53 Tumor Suppressor; Phosphoprotein p53; TP53; Transformation related protein ...
little is known about p53 turnover through proteasome-independent pathway(s). The digestive organ expansion factor (Def) protein is essential for the development of digestive organs. In zebrafish, loss of function of def selectively upregulates the expression of p53 response genes, which raises a ...
甾醇调节基本结合蛋白 1c(sterol regulatory element binding protein 1c, SREBP1c)和甾醇调节基本结合蛋 白 2(sterol regulatory element binding protein 2, SREBP2)作为碱性螺旋环亮氨酸拉链转录因子的家族成员,在脂质代谢的调节中起核心作用[...