These facts suggest the significant role of these genes in the genesis and progression of various tumors. The present study was designed to assess the significance of p53 and Bcl-2 protein (pBcl-2) expression on resectable invasive ductal carcinoma (IDC) of the pancreas....
This chapter will review some of the origins of research into the p53 gene and its protein. This will form a basis for understanding the other chapters of this book and provide a foundation upon which new facts are built. It also points to important future directions for this field. This ...
p53 serves as a quality control protein that assures the integrity of the regeneration process. When p53 function is lost, the regeneration process is impaired leading to cancer development Cell Death and Differentiation preservation of DNA fidelity and tumor-suppressor activities are crucial to ensure...
p53 protein, in both cases leading to loss of transcriptional activity and tumor-suppressor capabilities.3 Mutations in the TP53 gene may also convey an additional selective advantage for tumors, as the mutant p53 (mutp53) protein may acquire cancer-promoting activities, augmenting cell migration, ...
31 When activated, the p53 protein functions as a transcriptional regulator, hence initiating a cascade of events that determines the cellular outcome including cell cycle arrest, apoptosis, senescence, DNA repair, development, differentiation and tissue homeostasis.32 Interestingly, all these cellular ...
表1大肠上皮恶性转化不同阶段Fas mRNA, p53蛋白阳性表达和凋亡细胞密度(mean±SD/0.1 024 mm2). 分组Fas mRNA阳性 p53蛋白阳性 凋亡细胞 n密度n密度n密度 非肿瘤黏膜539.60±6.51bd68.40±2.67fh615.02±11.14 管状腺瘤2250.93±21.64bd2313.19±8.95fh2446.31±18.86jl ...
Although increases in wild type p53 protein in ML-1 cells resulted in increases in a p53 target gene, p21cipl/wafl/sdil, this effect was not observed in Raji cells which express a mutant p53 protein. 展开 关键词: deferoxamine, cells, raji cells, genes, cell growth, nutrient deficiencies,...
The p53 protein inhibits the amyloid cascade by repressing the transcription of BACE1. Additionally, p53 inhibits the mTOR signaling pathway, resulting in Aβ protein clearance through the induction of autophagy. However, Aβ peptides may prevent these neuroprotective p53 effects through post...
p53 protein expression in breast carcinoma. Cooperative study with wild type p53 induced proteins MDM2 and p21/WAFl. Anticancer Res 1997;17:2123–2127. PubMed CAS Google Scholar Momand J, Zambetti GP, Olson DC, George D, Levine AL. The mdm2 oncogene product forms a complex with the p53...
The p53 tumor-suppressor plays a critical role in the prevention of human cancer. In the absence of cellular stress, the p53 protein is maintained at low steady-state levels and exerts very little, if any, effect on cell fate. However, in response to var