T Megha,F Ferrari,A Benvenuto, et al.p53 mutation in breast cancar, correlation with cell kinetics and cell of origin. J Clin Pathol . 2002Megha T, Ferrari F, Benvenuto A, Bellan C, Lalinga AV, Lazzi S, et al. P53 mutation in breast cancer. Correlation with cell kinetics and cell ...
4.Silwal-Pandit L, Vollan HK, Chin SF, Rueda OM, McKinney S, Osako T, Quigley DA, Kristensen VN, Aparicio S, Børresen-Dale AL, Caldas C, Langerød A. TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance. Clin Cancer Res. 2014 Jul 1;20...
The tumour suppressor gene TP53 is the most frequently mutated gene in cancer. Wild-type p53 can suppress tumour development by multiple pathways. However, mutation of TP53 and the resultant inactivation of p53 allow evasion of tumour cell death and rapid tumour progression. The high frequency of...
This aminoacid residue is highly conserved in many species, thus suggesting that such mutation plays an important role in the loss of wt-p53 function. Previous article in issue Next article in issue Keywords p53 Mutation SSCP Breast cancer
Molecular epidemiology of human cancer risk: gene-environment interactions and p53 mutation spectrum in human lung cancer. The p53 tumour suppressor gene is at the crossroads of a network of cellular pathways including cell cycle checkpoints, DNA repair, chromosomal segregation... WP Bennett,SP Hussa...
Figure 6. High Pin1 Levels Influence the Prognostic Value of p53 Missense Mutation in Breast Cancer (A) Kaplan-Meier survival curves of breast cancer patients (observation threshold 10 years, clinical variable = OS) as a function of the combination of Pin1 overexpression and presence of p53 mis...
Furthermore, it could cause multidrug resistance in breast cancer cells. Interestingly, we found that GTSE1 could regulate the p53 function to alter the cell cycle distribution dependent on the mutation state of p53. Conclusion: Our results reveal that GTSE1 played a key role in the progression...
Cancer Mutation Oncogenesis Tumour suppressors Nature Cell Biology (Nat Cell Biol)ISSN1476-4679(online)ISSN1465-7392(print) Sign up for theNature Briefing: Cancernewsletter — what matters in cancer research, free to your inbox weekly. Email address ...
p53 mutations in the primary tumor were detected in 46 of 126 ( 36.5% ) breast cancer patients. Of these 46 patients, 30 (65.1%) were also found to have p53 mutations in their plasma DNA. p53 mutation in plasma DNA was closely correlated with clinical stage, tumor size, lymphnode (LN...
In this study we present data linking specific mutations in the P53 gene to primary resistance to doxorubicin therapy and early relapse in breast cancer patients. 展开 关键词: Humans Breast Neoplasms Doxorubicin Antibiotics, Antineoplastic Treatment Outcome Drug Resistance, Neoplasm Mutation Genes, p53 ...