To further develop this class of compounds, we examined the effect of a few key structural features on the anticancer structure鈥揳ctivity relationship (SAR) in ALL cells. The active analogs showed comparable cytotoxicity and upregulation of p53 but did not induce significant downregulation of MDM2...
The p53 tumor suppressor gene has been implicated in the regulation of apoptosis in a number of different neuronal death paradigms. Because of the importance of p53 in neuronal injury, we questioned the mechanism underlying p53-mediated apoptosis in neurons. Using adenoviral-mediated gene delivery, ...
reflected in upregulation of p53 and CDKN1A (p21) by nutlin-3, and down regulation of c-MYC by CPI203 (irrespective ofTP53status) (Fig.1c, d). To compare the effects of the single drugs and combination on viability of these 6 cell lines, we used resazurin (a metabolic viability senso...
The p53-dependent pathway is critically implicated in DDR [4,5,6]. p53 can transcriptionally induce expression of apoptotic genes Bax and PUMA-α (p53 upregulated modulator of apoptosis-α), leading to caspase-3 activation and cell death. It can increase expression of p21, resulting in senesce...
p53 upregulated modulator of apoptosis SIRT1 sirtuin 1 THC Δ9-tetrahydrocannbidiol Veh vehicle WT wild-type 1. Introduction Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, affecting more than 25% of the human population, and a leading ...
-type p53 (wt p53) function of a temperature-sensitive p53 (p53ts) transgene in M1 myeloblasts leukemia cells, which do not express endogenous p53, the spectrum of p53 target genes has been broadened to include bcl-2 and bax,12,13 gene products implicated in the regulation of apoptosis....
Fig. 1 DJ-1 is upregulated in colorectal cancer tissues A-B:Immunohistochemistry staining of DJ-1 in colorectal cancer tissues;C-D:Western blot analysis of DJ-1 from colorectal cancer tissues and adjacent normal ...
The Molecular Mechanism of Noxa-induced Mitochondrial Dysfunction in p53-Mediated Cell Death Genotoxic stresses stabilize the p53 tumor suppressor protein which, in turn, transactivates target genes to cause apoptosis. Although Noxa, a "BH3-only" m... YW Seo,JN Shin,KH Ko,... - 《Journal of...
Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. Among these unconventional activities, an iron-dependent fo...
In contrast, p53-mediated apoptosis from bortezomib-induced stress is transcription-dependent. Interestingly, we also found that doxorubicin-induced p21 expression is activated by p53 in transcription-dependent manner, while camptothecin-induced p21 expression is p53-independent. We then investigated the ...