How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Cell Death Differ. 2018;25(1):104-113.Aubrey BJ, Kelly GL, Janic A, Herold MJ and Strasser A: How does p53 induce apoptosis and how does this relate to p53‑mediated tumour ...
The tumour suppressor gene TP53 is mutated in ~50% of human cancers. In addition to its function in tumour suppression, p53 also plays a major role in the response of malignant as well as nontransformed cells to many anticancer therapeutics, particularly
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. The tumor suppressor p53 inhibits tumor growth primarily through its ability to induce apoptosis. Mutations in p53 occur in at least 50% of human tumors. W... VJN Bykov,N Issaeva,A Shilov,... ...
Cell cycle/apoptosis molecule expression correlates with imatinib response in patients with advanced gastrointestinal stromal tumors. Altered expression of cell cycle/apoptosis key regulators may promote tumor progression, reflect secondary genetic/epigenetic events, and impair the effect... S Romeo,M Debie...
A different magnitude of p53 binding protein 1 (53BP1) recruitment contributed to diverse capsaicin-induced genotoxic effects in DU145 and A549 cells. Capsaicin was also found to be a DNA hypermethylating agent in A549 cells. In summary, we have shown that genotoxic effects of capsaicin may ...
Find out more about this natural mechanism to get rid of damaged cells before they turn cancerous. Which turmeric compounds promote apoptosis?
These data suggest that p21 inhibits proliferation in a p53-dependent or independent manner but does not mediate p53-induced apoptosis in urothelial carcinoma cells. 展开 关键词: cell cycle, transfection, Western blot, RT-PCR, CIP1, retinoblastoma ...
This process may be mediated by overexpression of p53 suppressor gene. While DR accelerates the expression of Fas antigen, this result does not influence the rate of apoptosis of hepatocytes under physiological conditions. 展开 关键词: Hepatocytes Dietary restriction Cell proliferation Apoptosis ...
Mutationally activated PIK3CA(H1047R) cooperates with BRAF(V600E) to promote lung cancer progression. Cancer Res 2013; 73: 6448–6461. CAS PubMed Google Scholar Bennett WP . p53 alterations in progenitor lesions of the bronchus, esophagus, oral cavity, and colon. Cancer Detect Prev 1995; ...
Gemcitabine-induced apoptosis in a drug-resistant mouse leuke‐ mia L1210 cell line that does not express p53. Advances in Enzyme Regulation 2004;44 11-25.Cory AH, Cory JG. Gemcitabine-induced apoptosis in a drug-resistant mouse leukemia L1210 cell line that does not express p53. Adv ...