Controlofapoptosisbyp53 Thep53tumorsuppressor Oneofthemostimportantp53functionsisitsabilitytoactivateapoptosis. promotetumorprogressionandchemoresistance disruption P53 M G2 G1 S cellcyclearrest DNArepair cellcyclerestart apoptosis deathandelimination ofdamagedcells cellularandgeneticstability ATM,ATR DNAdamage,hyp...
S., and Lowe, S. W. (2003) Control of apoptosis by p53. Oncogene 22, 9030 -9040Fridman JS, Lowe SW. Control of apoptosis by p53. Oncogene 22: 9030-9040, 2003.Fridman JS,Lowe SW.Control of apoptosis by p53.Oncegene. 2003Fridman J.S. & Lowe S.W. (2003) Control of apoptosis ...
The BCL-2 protein family principally determines whether a cell commits to apoptosis and hence has crucial roles in development, tissue homeostasis and immunity. Consequently, alteration of this control can either promote cancer and autoimmune diseases (too little apoptosis) or augment ischaemic conditions...
functions of p53, recent studies in Drosophila have unraveled intriguing roles of Dmp53 in promoting cell division in apoptosis-induced proliferation, enhancing fitness and proliferation of the winner cell in cell competition and coordinating growth at the organ and organismal levelin the presence of ...
However, p53-dependent apoptosis is not always achieved by p53-reactivating compounds such as Nutlin-3a, although full transcriptional activity of p53 could be obtained. Here we investigated whether integrin α5β1 functional inhibition or repression could sensitize glioma cells to Nutlin-3a-induced ...
1). These activities can be tumour suppressive, but the protective functions of p53 can also play a role in limiting other pathologies and may - paradoxically - contribute to malignant progression. 3.2.1. DNA damage While some cells respond to DNA damage by activating p53-dependent apoptosis, ...
The SF-21 insect cell line undergoes rapid and widespread apoptosis when treated with actinomycin D or when infected with a mutant of the baculovirus Autographa californica nuclear polyhedrosis virus lacking a p35 gene or a functionally active iap (inhibitor of apoptosis) gene. Here we provide evide...
. ER stress also prevents p53 activation and p53-mediated apoptosis in response to DNA damage. These findings demonstrate that ER stress utilizes mechanisms that are distinct from other types of stress to modulate p53. In addition, they reveal that ER stress and nuclear DNA damage can induce ...
p53 is the best-known human oncosuppressor protein, and its genetic/epigenetic inactivation has been observed in more than 50% of all human cancers. p53 mostly mediates tumor suppression by transactivating pro-apoptotic and cell cycle arresting genes, but also by favoring mitochondrial apoptosis in...
RNAi against BCL-xL restored the UV-sensitivity of old cells, indicating that BCL-xL is itself responsible for the pre-senescence decline in the ability of a genotoxic stress to induce apoptosis. 展开 关键词: Apoptosis Pre-senescence Ultraviolet BCL family BAX BCL-xL p53 ...