How does p53 induce apoptosis and how does this relate to p53-mediated tu- mour suppression? Cell Death Differ 2018; 25: 104-113.Aubrey BJ, Kelly GL, Janic A, Herold MJ, Strasser A. How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Cell Death ...
The tumour suppressor gene TP53 is mutated in ~50% of human cancers. In addition to its function in tumour suppression, p53 also plays a major role in the response of malignant as well as nontransformed cells to many anticancer therapeutics, particularly
41 Layers of p53 regulation L. Friedel and A. Loewer the expression of several hundreds of genes [2] and is thereby able to induce cell fates ranging from cell cycle arrest to senescence and apoptosis upon DNA damage [3]. Many tumours have mutations either of p53 itself or of members of...
Phosphorylation of p53 prevents MDM2 association and degradation; O-GlcNAc inhibits phosphorylation, increasing the stability of p53. Once stable, p53 induces transcription of p21. p21 is an inhibitor of CDKs and prevents cell cycle progression. OGT or OGA overexpression can directly induce p21 ...
Hague A, Manning AM, Hanlon KA, Huschtscha LI, Hart D, Paraskeva C (1993) Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-independent pathway: implications for the possible role of dietary fibre in the prevention of large-bowel cancer. Int J Cancer 55:498–...
Apoptosis has been established as a mechanism of anti-cancer defense. Members of the BCL-2 family are critical mediators of apoptotic cell death in health and disease, often found to be deregulated in cancer and believed to lead to the survival of malign
Cell death is important for maintaining cell number and preventing aberrant cell growth, which leads to cancer. There are three mechanisms of cell death: necrosis, asutophagy and apoptosis.Answer and Explanation: CTL and NK cells induce apoptosis through the Fas mediated signalling pathway....
Liver cancer in vitro Emodin 50 mM STAT3 and SHP-1 Inhibit growth of STAT3 and induce hepatocellular carcinoma apoptosis [63] Liver cancer in vitro Chrysophanol 25−120 μM ATP and LDH Stimulate necrotic cell death [64] Liver cancer in vitro Aloe-emodin 1−20 μg/mL P21,P53 and ...
P53 is a transcription factor that can cause cells to be eliminated by apoptosis or senescent-like arrest upon its activation by irreparable genetic damage, excessively expressed oncogenes, or a broad spectrum of other stresses. As P53 executes life and death decisions, its activity must be string...
Apoptosis has been established as a mechanism of anti-cancer defense. Members of the BCL-2 family are critical mediators of apoptotic cell death in health and disease, often found to be deregulated in cancer and believed to lead to the survival of malign