How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Cell Death Differ. 2018;25(1):104-113.Aubrey BJ, Kelly GL, Janic A, Herold MJ and Strasser A: How does p53 induce apoptosis and how does this relate to p53‑mediated tumour ...
The tumour suppressor gene TP53 is mutated in ~50% of human cancers. In addition to its function in tumour suppression, p53 also plays a major role in the response of malignant as well as nontransformed cells to many anticancer therapeutics, particularly
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. The tumor suppressor p53 inhibits tumor growth primarily through its ability to induce apoptosis. Mutations in p53 occur in at least 50% of human tumors. W... VJN Bykov,N Issaeva,A Shilov,... ...
p53 is frequently mutated in cancer and as a result is one of the most intensely studied tumour suppressors. Analysis of the primitive forms of p53 found in Caenorhabditis elegans and Drosophila, alongside studies using transgenic mouse models, indicate that the induction of apoptosis is both the ...
Hague A, Manning AM, Hanlon KA, Huschtscha LI, Hart D, Paraskeva C (1993) Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-independent pathway: implications for the possible role of dietary fibre in the prevention of large-bowel cancer. Int J Cancer 55:498–...
P53 is a transcription factor that can cause cells to be eliminated by apoptosis or senescent-like arrest upon its activation by irreparable genetic damage, excessively expressed oncogenes, or a broad spectrum of other stresses. As P53 executes life and death decisions, its activity must be string...
The damage or error theories emphasize the role of environmental assaults on living organisms that induce cumulative detrimental effects at various levels as the cause of ageing [4] (Table 1). In 2013, the “Hallmarks of ageing” were defined and assigned to three main categories: primary, ...
Metformin is a first-line drug used for the treatment of type 2 diabetes; on the basis of its massive regulatory network, many studies have shown that metformin can induce cell cycle arrest, autophagy and apoptosis to exert antitumour effects [60], [61], [62]. Recent studies have shown ...
TP53 3KR, a mutant that does not induce cycle arrest, cellular senescence, or apoptosis but still suppresses tumour forma- tion (Figure 3).77 Jiang et al. showed that TP53 3KR inhibits cystine uptake and sensitizes cells to ferroptosis by repressing expression of SLC7A11.76 The mechanism of...
a mutant that does not induce cycle arrest, cellular senescence, or apoptosis but still suppresses tumour formation (Figure 3).77Jianget al.showed that TP53 3KR inhibits cystine uptake and sensitizes cells to ferroptosis by repressing expression of SLC7A11.76The mechanism of action appears to be ...