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8. Jiandong Chen, et al. The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression. Cold Spring Harb Perspect Med. 2016 Mar 1;6(3):a026104. 9. Alexei Vazquez, Gareth L Bond, et al. The genetics of the p53...
Up-regulation of LINC01010 and lncRNA CASC15 can regulate the p53 signaling pathway and apoptosis process by regulation of PERP expression level as a breas... M Karimi,ZF Novin,A Naghieh,... 被引量: 0发表: 2022年 The ARF/p53 pathway The ARF tumor suppressor connects pathways regulated ...
[8].Bakhoum S F, Cantley L C. The multifaceted role of chromosomal instability in cancer and its microenvironment[J]. Cell, 2018, 174(6): 1347-1360. [9].Chattopadhyay S, Marques J T, Yamashita M, et al. Viral apoptosis is induced by IRF‐3‐mediated activation of Bax[J]. The EM...
[1] Li, T., Kon, N., Jiang, L., Tan, M., Ludwig, T., Zhao, Y., Baer, R., and Gu, W. Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell 149, 1269-1283 (2012). [2] Jiang, L., Kon, N., Li, T., Wang, S.-J., Su...
8. Jiandong Chen, et al. The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression. Cold Spring Harb Perspect Med. 2016 Mar 1;6(3):a026104.9. Alexei Vazquez, Gareth L Bond, et al. The genetics of the p53 pathway, apoptosis and cancer therapy. Nat Rev ...
在这方面,许多文献表明,p53通过调控代谢基因的表达来实施这种代谢调控,如p53诱导的糖酵解和凋亡调节因子(TIGAR)和葡萄糖转运蛋白;细胞色素c氧化酶2、谷氨酰胺酶2和苹果酸酶的合成;或蛋白质与代谢酶的相互作用,如葡萄糖-6-磷酸脱氢酶、过氧化物酶体增殖物激活受体γ辅活化子-1和SREBP(Humpton and Vousden, ...
调节野生型 p53功能的重要分子是p53凋亡刺激蛋白2 (apoptosis stimulating protein of p53 2,ASPP2) 家族[1]。ASPP 家族由 3 个成员 ASPP1、ASPP2 和 iASPP 组成,分别由定位于不同染色体上的 3 个不同基因编码,ASPP1 位于 14q32.3...
determinant in colon cancer risk and progression and established that metabolism of butyrate, a short-chain fatty acid generated during the fermentation of fiber by endogenous intestinal bacteria, induces mitochon drial function-dependent growth arrest and apoptosis of colonie carci noma cells in vitro....
1. Vassilev LT, Vu BT, Graves B, et al. In vivo activation of the p53 pathway by small-...