If there is truth in this statement, then it has much to do with the ability of this protein to induce programmed cell death, or apoptosis. First discovered in 1979 as a protein complexed with the large T antigen of SV40 virus (Lane and Crawford, 1979; Linzer and Levine, 1979), the ...
p53 Is Associated with the Nuclear Envelope in Mouse Testis p53 has been postulated to play a role in meiosis as well as in the regulation of germ cell numbers by apoptosis. This study investigated the subcellular l... Y Yin,WC Dewolf,A Morgentaler - 《Biochemical & Biophysical Research Comm...
Since p53 has important functions over the regulation of the cellular cycle, proliferation, and apoptosis, it is subject to strict regulation. The degradation of p53 occurs in the proteasome, and depends on its ubiquitination by Mdm2 (murine double minute 2). Hyperglycemia affects the concentration...
The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res 1994; 54: 614–617. CAS PubMed Google Scholar Valente LJ, Gray DH, Michalak EM, Pinon-Hofbauer J, Egle A, Scott CL et al. p53 efficiently suppresses...
The p53 tumour suppressor gene: a mediator of a G1 growth arrest and of apoptosis The tumour suppressor gene p53 plays a major role in the protection of cells from DNA damage. Activation of the protein in response to irradiation or genot... E Yonish-Rouach - 《Experientia》 被引量: 185...
Cellular senescence is thought to play an important role in tumor suppression and apoptosis resistance. However, the relationships among stress-induced premature senescence (SIPS), tumorigenesis and apoptosis induced by UVB remain unknown. We developed a model of UVB-induced premature senescence in ...
(KO) mice demonstrate the important role of this protein in maintaining DNA integrity,12 and several benzamide-derived PARP inhibitors are being tested to treat cancer patients.13,14 One of the targets of PARP-1 is p53,15–18 promoting its poly(ADP- ribosyl)ation and accumulation in the ...
The canonical role of p53 in preserving genome integrity and limiting carcinogenesis has been well established. In the presence of acute DNA-damage, oncogene deregulation and other forms of cellular stress, p53 orchestrates a myriad of pleiotropic processes to repair cellular damages and maintain homeos...
Here, we have examined the role of p53 in the response to 5-aza-2'-deoxycytidine (5-aza-dC or decitabine). Primary mouse embryonic fibroblasts deficient for p53 undergo apoptosis after treatment with 5-aza-dC. When compared with other demethylating drugs or chemotherapeutic treatments, 5-aza...
Taylor & Francis Online :: Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells - Cell Cycle - Volume 8, Issue 10 Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells. Cell Cycle 2009 ; 8:1478 - 83; http://...