Varmeh-Ziaie S, Okan I, Wang Y, Magnusson KP, Warthoe P, Strauss M, Wiman KG (1997) Wig-1, a new p53-induced gene encoding a zinc finger protein. Oncogene 15:2699–26704. PubMed CAS Google Scholar Wasylyk C, Salvi R, Argentini M, Dureuil C, Delumeau I, Abecassis J, Debus...
p53-encoding plasmidp53 is a tumour suppressor gene that has been explored for cancer gene therapy as a possible alternative to the common treatments. The use of plasmid DNA (pDNA) to carry the therapeutic gene has been considered, but it is requisite to preserve its supercoiled (sc) ...
The gene encoding p53 (TP53) was first thought to be an oncogene that mediated the pathological effects of experimental DNA tumour viruses and chemical carcinogens. However, after 10 years of research TP53 was found to be a tumour suppressor gene that is often inactivated in human cancers. The...
The gene encoding p21 (CDKN1A) is the first transcriptional target identified for p53.55p21 is a potent inhibitor of binding to cyclin-dependent kinases (CDKs), which inhibits cell cycle proteins and further inhibits phosphorylation of Rb by the cyclin D1-CDK4, cyclin D2-CDK4 and cyclin E-...
253, 254 Particularly interesting are results with a fiber mosaic Ad5 vector encoding two fibers: the σ1 and the wt Ad5 fiber.255 This mosaic transduces some primary OS cell lines even more efficiently than AdCMVlucRGD (V Ternovoi, unpublished data, 2005). Recently, selective targeting of...
(11 bp), generated from defined positions within each mRNA molecule. Expression patterns are deduced from the abundance of individual tags. To induce apoptosis, the colorectal cancer line DLD-1, containing an inactive endogenous p53 gene, was infected with a replication defective adenovirus encoding ...
et al. Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia. Am. J. Hum. Genet. 96, 1001–1007 (2015). 42. Wang, A. T. et al. A dominant mutation in human RAD51 reveals its function in DNA interstrand crosslink repair independent of homologous ...
mediated by the protein p14ARF. Some oncogenes can also stimulate the transcription of proteins which bind to MDM2 and inhibit its activity. Once activated p53 activates expression of several genes including one encoding for p21. p21 binds to the G1-S/CDK and S/CDK complexes (molecules import...
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Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation. Nature 1984, 312, 649–651. [Google Scholar] [CrossRef] Wolf, D.; Harris, N.; Rotter, V. Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional ...