The researchers were surprised to discover they could use the on-off switch to target the majority of genes in the human genome, even those that don’t make proteins. The UCSF/MIT team wanted to get a sense of whether CRISPRoff would be applicable to m...
Dr. Bonni and colleagues are working on figuring out the mechanism by which changes in gene activity lead to changes in brain cell activity. “This enzyme is related to other enzymes that are mutated in neurodevelopmental diseases,” Bonni pointed out. “The ability to turn off genes turns out...
Researchers have found that the fungusColletotrichum tofieldiaecan both support and inhibit plant growth, depending on the activation of a specific gene cluster. This discovery challenges traditional distinctions between harmful pathogens and beneficial microbes. Understanding and harnessing thes...
Bacterial transcription: Turning the switch on gene expressionThe article discusses the structural changes of the metabolite-binding riboswitches to regulate transcription or translation of downstream genes to switch on gene expression.doi:10.1038/nrmicro3356Du Toit...
Drug resistance is one of the most difficult challenges facing tuberculosis (TB) control. Drug efflux is among the mechanisms leading to drug resistance. In our previous studies, we partially characterized the ABC-type MSMEG-3762/63 efflux pump in Mycoba
Secretory granule biogenesis and chromogranin A: master gene, on/off switch or assembly factor? Secretory granules are found in specialized cell types, including endocrine cells, suggesting that a coordinated programme of gene expression is involved i... R Day,SU Gorr - 《Trends in Endocrinology ...
德国QIAGEN,货号:5000-1505,Switch ON-OFF 120V, HTR1 价格电议 起批量≥1 盒 最小起订1盒 供货总量66盒 发货地址广东省深圳市 建议售价￥0/盒 更新日期2025年01月17日 即时洽谈立即询价查看联系方式 收藏产品发送留言 VIP9年 深圳子科生物科技有限公司 ...
in 1 s ON-1 s OFF periods. In the case of DRG neurons, stimulation was applied 2 h after seeding. For cortical neurons, two different stimulation time-points after the axotomy were assessed: 30 min after axotomy and 6 h after axotomy. To assess neuronal activation, neurons were fixed ...
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Fluorescence activation involved ligand-dependent chromophore maturation with turn-on ratios of up to 62-fold in cells and 100-fold in vitro. Endoplasmic reticulum- and mitochondria-localized ATOM sensors detected ligands that were targeted to those organelles. The ATOM design was validated with three...