The changes in the transcriptional activity of K19 and K18 genes, observed in male gonads, occur characteristically at the very beginning of testicular differentiation. In the male pathway of sexual differentiation, the switch in K19/K18 gene expression is, in addition to the activation of the ...
CD40: an upstream master switch for endothelial cell activation uncovered by RNAi-coupled transcriptional profiling The CD40-CD154 dyad seems to play a prominent role fostering the immune-inflammatory response triggered by endothelial cell (EC)-T-cell communication. To d... R Pluvinet,R Olivar,J...
Each (or each second) transition from one state to the other causes a switch from one structure-controlling gene to the next. This enables a counting of alternations on the DNA-level and a high resolution in the corresponding activation of control genes. The model explains the formation of ...
Cancer driver genes are classified as oncogenes (OGs) or tumor suppressor genes (TSGs) depending upon whether their activation or inactivation contributes to cancer. Whereas a single mutation in an OG can be sufficient to increase tumor fitness, inactivation of both copies of a TSG is often requ...
These alterations lead to the formation of numerous cancer-specific mRNAs translated to misfunction proteins and/or proteins with changed expression levels. Such changed proteins can result in the activation of oncogenes or the inactivation of tumor-suppressor genes42,43....
and Shen,Y.F. (2010) A switch from hBrm to Brg1 at IFNgamma-activated sequences mediates the activation of human genes. Cell Res., 20, 1345-1360.Zhang Y, Cheng MB, Zhang YJ, et al. A switch from hBrm to Brg1 at IFNc-activated sequences mediates the activa- tion of human genes...
Induction of cytokine synthesis by flagella from gram-negative bacteria may be dependent on the activation or differentiation state of human monocytes. We have previously demonstrated that salmonellae, but not Escherichia coli or Yersinia enterocolitica, stimulates tumor necrosis factor alpha (TNFalpha) ...
Cis-acting elements serve as a molecular switch by binding to transcription factors, which are associated with gene transcription initiation and activity. To explore the putative functions of CqTH genes, we extracted and examined the 1500 bp sequences upstream of the transcription start site to id...
Yellow highlighted area represents day and the gray area designates night. Lines with blunt arrows show inhibition and lines with pointed arrows indicate activation. Solid circles next to TOC1, LUX, and LHY stand for feedback inhibition. The middle green shaded region shows signaling and ...
Interestingly, we observed significant difference between DNA methylation changes at tumor-specific TE-eQTLs than shared TE-eQTL loci (eQTL active in both normal and cancer) which pinpoints that DNA methylation changes at these specific loci to be one of the causes of the activation of these ...