The researchers were surprised to discover they could use the on-off switch to target the majority of genes in the human genome, even those that don’t make proteins. The UCSF/MIT team wanted to get a sense of whether CRISPRoff would be applicable to ma...
Switch-on of the substance P gene at birth in respiration-related nuclei in the rabbitEarly Human Development
“We identified two key points: First, on the fungal side, thatCt3activates the ABA-BOT biosynthesis gene cluster; and second, on the plant side, thatCt3induces the host plant’s ABA signaling pathways, through which the fungus inhibits plant growth,” explained Hiruma. The re...
The job of some proteins inside cells is to switch other important proteins on or off. Understanding how these proteins work and which proteins they target could be the key to whynerve cellsdie in Parkinson's - and how we can save them. But despite intensive research, the target of the P...
Widespread use of gene therapy technologies is limited in part by the lack of small genetic switches with wide dynamic ranges that control transgene expression without the requirement of additional protein components1–5. In this study, we engineered a c
Allosteric effects: An on-off switch A model for allosteric effects is described in which conformational changes induced by binding at one site alter the receptivity of a remote binding site. The system involves a 2,2′-bipyridyl function attached at the 3,3′-positions to ... J Rebek,L ...
The authors explored the genetic master circuit of HIV, the Tat circuit, and built upon previous work by Weinberger which showed that it did not function like a standard on-off switch (a light switch, for example). Weinberger’s previous work found that the HIV circuit is driven by cellular...
As the wild-type IDH1 may act as a tu- mor suppressor in part through suppression of the HIF1α pathway by αKG [12], our results provide insights into the mechanism of the "off switch" of the potential tumor suppressive function of IDH1 by the R132H mutation. Furthermore, our ...
In conclusion, we have identified an on/off switch, CGA, that controls dense-core secretory granule biogenesis in endocrine cells. The synthesis of CGA itself can be regulated by hormones. Thus, CGA serves an important higher-order physiological role in controlling hormone secretion through regulatin...
put ontake off put one put ones foot into on put oneself in sbs pl put poisons into othe put sb in the ring put some oil put some tenderness i put someone at a disa put someone down put someone out of he put something out of put sth in low places put sth to athe vote put sty...