Chemogenetic ON and OFF switches for RNA virus replication Therapeutic application of RNA viruses requires tight control over viral activity. Here the authors design a regulatory switch that enables control over activity with clinically approved HIV protease inhibitors. ...
Gene switch-off produces healthier carbohydrates 来自 mbg.au.dk 喜欢 0 阅读量: 27 作者: 21256@au.dk 摘要: For the first time ever scientists have succeeded in producing a crop containing only healthy carbohydrates. Easily digestible starch, which is the lesser healthy version of carbohydrates...
Researchers are developing molecular switches that can inactivate transplanted genes, paving the way for safer gene therapies. First up—better treatments for cancer
The switch gene, Sex-lethal (Sxl), controls sexual development and dosage compensation. It must be active in females and inactive in males throughout development. Analysis of Sxl cDNAs shows that this on/off regulation may be explained by differential RNA splicing; only female transcripts appear ...
Our theoretical results show that the time delay can induce the switch, i.e., the TF-A monomer concentration shifts from the high concentration state to the low concentration state ("on"→"off"), and can further accelerate the transition from "on" to "off". Moreover, it is found that...
Before comparison, we need to apply same steps in I-1 and I-2 on the cells from Path2 to identify switching pseudo-time point for each gene. sce_p2<-binarize_exp(sce_p2)sce_p2<-find_switch_logistic_fastglm(sce_p2,downsample=TRUE,show_warnings=FALSE) ...
FOUND: AN ON/OFF SWITCH FOR CANCER; Scientists Discover New Antibiotic to Curb Killer GeneByline: LORRAINE FISHERThe Mirror (London, England)
genetic interactions switch from positive (suppressive) to negative (enhancing) as the expression of the gene changes. These seemingly complicated changes can be predicted using a mathematical model that propagates the effects of mutations on protein folding to the cellular phenotype. More generally, ...
Rust fungi are biotrophic basidiomycete plant pathogens that cause major diseases on plants and trees world-wide, affecting agriculture and forestry. Their biotrophic nature precludes many established molecular genetic manipulations and lines of research
Figure 2C shows the performance of the switch in such a configuration using one of the clones generated. In the ON state, most cells displayed strong GFP fluorescence, whereas in the OFF state, only two cells were visible with fluorescence microscopy although the phase contrast image shows a ...