The researchers were surprised to discover they could use the on-off switch to target the majority of genes in the human genome, even those that don’t make proteins. The UCSF/MIT team wanted to get a sense of whether CRISPRoff would be applicable to ma...
On and Off: Epigenetic Regulation of C. albicans Morphological SwitchesCANDIDA albicansEPIGENETICSGENE regulatory networksCHROMATINIMMUNOCOMPROMISED patientsSWITCHING systems (Telecommunication)The human fungal pathogen Candida albicans is a dimorphic opportunistic pathogen that colonises most of the human ...
RT-qPCR, targeting theMSMEG_3762gene, was performed to evaluate the expression of theMSMEG_3762/63/65operon inM. smegmatismc2155 under standard conditions and after exposure to sub-inhibitory concentrations of rifampicin and ciprofloxacin (oligonucleotides detailed in Supplementary TableS1). Analysis by ...
Indeed, the CGA gene contains an estrogen response element Iacangelo et al. 1991, Wu et al. 1991, and CGA mRNA is regulated by several hormones and second messengers (Iacangelo and Eiden, 1995). In conclusion, we have identified an on/off switch, CGA, that controls dense-core secretory ...
Researchers at the University of California, San Diego and Oak Ridge National Laboratory have discovered how a genetic circuit in HIV controls whether the virus turns on or stays dormant, and have succeeded in forcing the virus towards dormancy, a findin
Our variant ribozymes enabled in vivo regulation of adeno-associated virus (AAV)-delivered transgenes, allowing dose-dependent and up to 223-fold regulation of protein expression over at least 43 weeks. To test the potential of these reversible on-switches in gene therapy for anemia of chronic ...
Lu and his colleagues built the circuit encoded in DNA based on principles similar to the simple AND gates used in electronics, which will only switch on a circuit when two inputs are present. Since cancer cells differ from normal cells in the profile of their gene expression, the researchers...
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Many miRNAs have been reported to be involved in various biological functions, including gene regulation. Variations in the expression of these miRNAs were found to be responsible for causing different diseases, including cancer. Specifically, changes in miRNA levels with oncogenic or cancer suppression...
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