(2013) Nuclear RNA surveillance: role of TRAMP in controlling exosome specificity. Wiley Interdiscip. Rev. RNA 4, 217-231.Schmidt, K., Butler, J.S., Nuclear RNA surveillance: role of TRAMP in controlling exosome specificity. Wiley Interdiscip Rev RNA 4, (217-31) (2013)....
These processes are subject to surveillance by nuclear RNA decay pathways to prevent the export of aberrant, or otherwise "non﹐ptimal," transcripts. However, unlike mRNA, many long ncRNAs are nuclear retained and those that maintain enduring functions must employ precautions to evade decay. Proper...
et al. Oncogenic CDK13 mutations impede nuclear RNA surveillance. Science 380, eabn7625 (2023). Article CAS PubMed PubMed Central Google Scholar Bresson, S. M., Hunter, O. V., Hunter, A. C. & Conrad, N. K. Canonical poly(A) polymerase activity promotes the decay of a wide ...
During nuclear surveillance in yeast, the RNA exosome functions together with the TRAMP complexes. These include the DEAH-box RNA helicase Mtr4 together with an RNA-binding protein (Air1 or Air2) and a poly(A) polymerase (Trf4 or Trf5). To better determine how RNA substrates are targeted...
RNA surveillance helicase SF2 DExH-box RNA-protein complex translocase exosome cryo-EM structure oncogene kinase Introduction RNA quality control pathways ensure the integrity of the transcriptome (Doma and Parker, 2007; Wolin and Maquat, 2019). Defective, unprocessed, or spurious coding and non-codi...
However, a substantial proportion of nuclear introns are likely short lived due to the tight coupling of transcription with pre-mRNA splicing, pre-mRNA quality surveillance, and rapid degradation via the nuclear exosome (Lee and Rio, 2015; Kilchert et al., 2016; Bresson and Tollervey, 2018)....
A clue to the question of rRNA degradation in the nucleolus was recently proposed in yeast: a surveillance pathway that eliminates defective 60S pre-ribosomal subunits after addition of poly(A) tails was described (LaCava et al. 2005). RNA degradation appears to occur preferentially within a sub...
Air proteins control differential TRAMP substrate specificity for nuclear RNA surveillance RNA surveillance systems function at critical steps during the formation and function of RNA molecules in all organisms. The RNA exosome plays a central ro... K Schmidt,Z Xu,DH Mathews,... - 《Rna-a Public...
(Li and Hochstrasser2003), implicated in DNA replication and repair, the formation and nuclear export of 60S ribosomal subunits as well as mRNA surveillance (Stelter and Ulrich2003; Zhao et al.2004a; Panse et al.2006; Lewis et al.2007; Palancade et al.2007) and reviewed in Palancade ...
RNA surveillance by the exosome cooperates with RNA processing to regulate mRNA levels. Both the induction of non-productive RNA processing (such as premature transcription termination or cryptic splicing) or the suppression of proper mRNA processing (resulting in intron retention or read-through transcr...