Zhang YE. Non-Smad signaling pathways of the TGF-beta family. Cold Spring Harb Perspect Biol. 2017;9:pii: a022129.Zhang, Y. E. (2017): Non-smad signaling pathways of the TGF-β family. Cold Spring Harbor Perspectives in Biology, vol. 9....
Transforming growth factor-β utilizes a multitude of intracellular signaling pathways in addition to Smads to regulate a wide array of cellular functions. These non-canonical, non-Smad pathways are activated directly by ligand-occupied receptors to rein
Transforming growth factor-β utilizes a multitude of intracellular signaling pathways in addition to Smads to reg-ulate a wide array of cellular functions.These non-canonical,non-Smad pathways are activated directly by ligand-occupied receptors to reinforce,attenuate,or otherwise modulate downstream cellu...
The two main downstream pathways of TGF-β signaling are the Smad-dependent and Smad-independent pathways [31, 50]. In our study, both were found to participate in TGF-β2-induced autophagy in glioma (Fig. 5a, c). TGF-β activates the PI3K-Akt-mTOR pathway during the TGF-β-induced ...
We investigated the effects of TGF-beta(1) on the cellular functions of intestinal epithelial cells, and also evaluated its signaling pathways in these cells.We used the rat IEC-6 intestinal epithelial cell line for these studies. The expression of TGF-beta(1)/Smad signaling molecules was ...
Thus, although Smad pathways were unaffected, non-Smad TGF-β signaling and complex biological processes were significantly attenuated (FIGURE 1, FIGURE 2, FIGURE 3, FIGURE 4). FAK can function as either a tyrosine kinase affecting multiple targets or as a scaffold through its various protein-...
aWnt Signaling and the Control of Human Stem Cell Fate Wnt信号和人的干细胞命运控制[translate] ahello honey , i am very happy now that you tell me what happen.. because i was worried before now when i came for lunch i try to talk to you so that heart my be at peace but you where...
Aims/hypothesis The TGF-β/MAD homologue (SMAD) and nuclear factor κB (NF-κB) signalling pathways have been shown to play a critical role in the d... S.,M.,Ka,... - 《Diabetologia》 被引量: 121发表: 2012年 TNFα represses BMP signaling by interfering with the DNA binding of smad...
Several signaling pathways and factors induce Ski and Skil gene expression; whereas, the TGF-β signaling pathway enhances or inhibits Skil gene expression via Smad2/4 or Smad3/4, respectively. Moreover, some miRNAs control the mRNA levels of these genes. The Ski and SnoN protein levels are ...
EMT is one of the key steps in cancer metastasis and TGF-β-induced signaling pathways are among the best studied mechanisms underlying cancerous EMT events, such as cell migration and cell invasion. We then examined TGF-β-induced EMT of RGS6-KD (RGS6-Cas9) NSCLC cells. Migration assay ...