Blocking TGF-β signaling in the embryonic pancreas, using a transgenic mouse expressing a dominant-negative TGF-β-type-II-receptor (DNTβRII) led to an increased number of endocrine cells arising from the embryonic ducts. The enhanced endocrine expansion was most prominent at E16.5, which ...
These effects are mediated by induction of canonical (Smad) as well as non-canonical (MAPK, Rho GTPase) signaling cascades. In the present review, we will highlight the non-canonical, Smad-independent signaling pathways activated by TGF-β2 in human TM cells, as well as the genes known to...
1)TGF-β/Smad signaling pathwaysTGF-β/Smad信号转导通路 1.Objective:To detect expression of the genes associated withTGF-β/Smad signaling pathwaysin RA patient and evaluate their effect in RA,evaluate their expressions in progress and outcome of RA patient,to investigate the ralation of those d...
The TGF-β family of ligands,including TGF-β,bone morphogenetic protein (BMP) and activin,signal through Smad pathways to regulate the fate of hematopoietic stem cells. TGF-β/Smad pathway may cause transcriptional activation of CD34 and preserve haematopoietic stem/progenitor cells activity. Also,...
参考文献:Chen CN, Chang HI, Yen CK, Liu WL, Huang KY. Mechanical Stretch Induced Osteogenesis on Human Annulus Fibrosus Cells through Upregulation of BMP-2/6 Heterodimer and Activation of P38 and SMAD1/5/8 Signaling Pathways. Cells. 2022 Aug 20;11(16):2600. doi: 10.3390/cells11162600. ...
The TGF-β and Wnt signaling pathways are interrelated in many cell types and tissues, and control cell functions in coordination. Here, we report that SMAD4, a downstream effector of the TGF-β signaling pathway, induces FZD4, a receptor of the Wnt sign
Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-beta-dependent responses in human mesangial cells Decaestecker M,Schnaper HW.Cross-talk between ERK MAP Kinase and Smad Signaling pathways enhances TGFbeta-dependent responses in human mesangial cells.The ... T Hayashida,M ...
(TGF-t3)一Smad signaling pathway has箍n important role in carcinogenesis.In recent years,many investigations have revealed that TGF-13super-family ligands, receptors,Smads protein,up stream and down stream regulators and cross—talk among many signaling pathways function in gastrointestinal cancers,lung...
[2]KatajistoP,VaahtomeriK,EkmanN,etal.LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis..NatGenet,2008,40(4):455-9. [3]Roberts AB.Is Smad3 a major player in signal transduction pathways leading to fibrogenesis?Chest,2001,120(Suppl.1):43S. [4]Maqi ...
In recent years, some investigations have revealed the functions of TGF-β super-family ligands, receptors, Smads protein, up stream and down stream regulators and cross-talk among many signaling pathways in gastrointestinal cancers, lung cancer and other cancers. This review attempts to collate and...