Zhang YE. Non-Smad signaling pathways of the TGF-β family. Cold Spring Harb Perspect Biol 2017; 9(2): a022129Zhang YE. Non-Smad signaling pathways of the TGF-beta family. Cold Spring Harb Perspect Biol. 2017;9:pii: a022129.Zhang, Y. E. (2017): Non-smad signali...
Transforming growth factor-β utilizes a multitude of intracellular signaling pathways in addition to Smads to regulate a wide array of cellular functions. These non-canonical, non-Smad pathways are activated directly by ligand-occupied receptors to reinforce, attenuate, or otherwise modulate downstream ...
Transforming growth factor-β utilizes a multitude of intracellular signaling pathways in addition to Smads to reg-ulate a wide array of cellular functions.These non-canonical,non-Smad pathways are activated directly by ligand-occupied receptors to reinforce,attenuate,or otherwise modulate downstream cellu...
We investigated the effects of TGF-beta(1) on the cellular functions of intestinal epithelial cells, and also evaluated its signaling pathways in these cells.We used the rat IEC-6 intestinal epithelial cell line for these studies. The expression of TGF-beta(1)/Smad signaling molecules was ...
Signaling pathways driving NAFL/NASH development and related therapeutic targets The development of NAFL/NASH is considered to initiate from simple steatosis as the first hit that is not enough to induce inflammation and fibrosis; however, during disease progression, a following second hit, including ...
Tgf-B1-activated SMAD signaling inhibits non-pathogenic gram negative bacteria-induced Nf-Kb recruitment to the Il-6 gene promoter through modulation of hi... Tgf-B1-activated SMAD signaling inhibits non-pathogenic gram negative bacteria-induced Nf-Kb recruitment to the Il-6 gene promoter through ...
Summary SnoN regulates multiple signaling pathways, including TGF-尾/Smad and p53, and displays both pro-oncogenic and anti-oncogenic activities in human cancer. We have observed previously that both its intracellular localization and expression levels are sensitive to cell density, suggesting that it...
Exosomal miRNAs has been demonstrated to be involved in the regulation of multiple signaling pathways during the development of viral hepatitis.561,562 Globally, hepatitis B virus (HBV) is the most common hepatitis and causes very heavy economic and heathy burden. According to Li et al. some exo...
The TGF-β signaling pathway outcome relies on the control of the spatial and temporal expression of >500 genes, which depend on the functions of the Smad protein along with those of diverse modulators of this signaling pathway, such as transcriptional factors and cofactors. Ski (Sloan-Kettering...
As a C2-WW-HECT-type ubiquitin ligase, Smad ubiquitination regulatory factor 1 (Smurf1) commonly serves to regulate ubiquitin-dependent protein degradation in a number of signaling pathways. Here, we report a novel function of Smurf1 in regulating Wnt/beta-catenin signaling through targeting axin...