We also highlight how these RNA molecules connect CR to its effects on genome stability, cell metabolism, programmed cell death, senescence, cancer, and neurodegeneration. We anticipate that an advanced understanding of the connections between CR and non-coding RNA will provide unique insights into ...
Non-coding RNAs (ncRNAs) are ribonucleic acid (RNA) molecules that are not translated into protein products. Different classes of non-coding RNAs participate in different cellular processes; for example, gene expression regulation (miRNAs, piRNAs, lncRNAs), RNA maturation (snRNAs, snoRNAs) and prot...
Long non-coding RNAs (lncRNAs) are RNA molecules over 200 nucleotides long, lacking protein-coding functions. Initially considered "junk" RNA, they are now recognized as crucial players in cellular processes like chromatin remodeling and gene expression regulation. Despite lacking coding potential, lncR...
Non-coding RNAsare functionalRNAmolecules that do not code for proteins. Only a few RNAs (less than 2%) are translated into proteins or are mRNAs, even though 90% of thehuman genomeis transcribed.57–60The rest of the transcribed RNAs are called non-coding RNAs that play a central role ...
W. In vitro selection of RNA molecules that bind specific ligands. Nature 346, 818–822 (1990). Article PubMed CAS Google Scholar Lee, H. K., Choi, Y. S., Park, Y. A. & Jeong, S. Modulation of oncogenic transcription and alternative splicing by β-catenin and an RNA aptamer in...
(lincRNA; located between protein-coding genes and at least 1 kb away from the nearest protein-coding genes), intronic (located within the intron of annotated protein-coding genes), anti-sense (RNA molecules that are transcribed from the opposite strand of many protein-coding genes), and ...
(shRNA), which are the precursors of siRNAs. miRNA, on the other hand, is single stranded and comes from endogenous non-coding RNA found within the introns of larger RNA molecules. However, the processing of shRNA into functional siRNA involves the same cellula...
different ncRNAs to the total amount of RNA in a healthy eukaryotic cell, other than rRNA (80–90%) and tRNA (10–15%), ranges between 0.002 to 0.2% [15]. On the contrary, RNA molecules that are of more than 200 bases in length are known as long non-coding RNA (lncRNA) [82]....
The widespread regulation of microRNA biogenesis, function and decay MicroRNAs are post-transcriptional regulatory molecules that control many developmental and cellular processes. Recent studies have revealed that microRNAs themselves are subject to sophisticated control at various levels, including biogenesis...
Phytohormones act as signaling molecules and play significant role in entire life cycle of a plant. The important phytohormones regulating growth and development of plant and managing stress response are auxin, cytokinin, gibberellin, abscisic acid, ethylene, jasmonic acid, salicylic acid and brassinoster...