1.和siRNA一样装载成RISC(RNA induced silencing complex , RISC;沉默复合物)后互补配对的mRNA降解; 2.miRNA可抑制mRNA的翻译,降低靶基因的蛋白质水平但不影响期mRNA的水平。 三、lncRNA(long non-coding RNA) IncRNA的长度一般大于200bp。根据基因组位点或相关的DNA特征,可以进一步进行分类(图4): 图4 长链非...
The remaining %98 of the genome consists of nonprotein-coding RNA, which is basically called non-coding RNA (ncRNA). Even though these noncoding transcripts are considered as transcriptional noise at the first sight, they have important roles in epigenetic mechanisms such as gene silencing, DNA ...
ncRNA为蛋白质编码的RNA分子,而是在细胞内执行其他功能。ncRNA基因有许多类型,其中一些包括: 转移RNA(tRNA):tRNA负责在蛋白质合成过程中将氨基酸带到核糖体上。有20种不同的tRNA基因,每种基因都编码一种特定的氨基酸。 核糖体RNA(rRNA):rRNA是核糖体的主要组成部分,是负责合成蛋白质的细胞机器。有几种不同类型的rR...
non-codingRNA(20-20000nt)RNAmRNA smallnon-codingRNA(sncRNA)(20-500nt)longnon-codingRNA(lncRNA)(>500-20000nt)Non-codingRNA:Versatilityinformandfunction NoncodingRNAgenesaresurprisinglynumerous.NoncodingRNAhaveaverydifferentfunctions.TimeforRNomics Cell,89:669–672,May30,1997 PNAS,97(26):14035-14037...
research achievements in the field of non coding RNA. This journal covers a wide range of research areas on non coding RNA, including but not limited to the recognition, structure, function, signaling pathways, transformation, and RNA analysis tools of miRNA, lncRNA, circRNA, piRNA, and others...
non-coding rna名词解释non-coding rna名词解释 非编码RNA(non-coding RNA,ncRNA)指的是在转录成RNA时不被翻译成蛋白质的RNA分子。与编码蛋白质的mRNA相比,ncRNA的功能非常多样,包括调控基因表达、RNA的剪接和稳定性、染色体转录后修饰等。非编码RNA是生物学研究领域中的一个热门话题,对于揭示细胞及多细胞生命现象的...
1、微小RNA(microRNA, miRNA) miRNA是短ncRNA,约为22～23个核苷酸,其编码基因由RNA多聚酶Ⅱ转录,通过与mRNA 3′端非翻译区(3′ untranslated region, 3′UTR)之间的结合调控mRNA的表达,超过60%的编码基因是miRNA的潜在调控靶点。 2、长链非编码RNA(long non-coding RNA, lncRNA) ...
collectively referred to as long noncoding RNAs (lncRNAs). A plethora of biological tissues, organs, pathological samples and cultured cells have been analyzed for noncoding RNA expression, and it is clear that these molecules are omnipresent. Apparently, defining noncoding RNA function has proven ...
Non-codingRNA(ncRNA)isaRNAmoleculethatfunctionsw/obeingtranslatedintoaprotein Mostprominentexamples:TransferRNA(tRNA),RibosomalRNA(rRNA) WhyNon-codingRNA Protein-codinggenescan’taccountforallcomplexity ncRNAisimportant!Generegulators QuickTime?andaTIFF(Uncompressed)decompressorareneededtoseethispicture....
Non-coding RNA Research(《非编码RNA研究》(英文),简称NCRNA)创刊于2016年12月,是由中国科学院主管,科学出版社主办,科爱公司运营的高质量国际开放获取期刊,旨在发表高水平的研究论文和综述,传播前沿研…