进一步在2020年他们推出了一种GeoMx™ Digital Spatial Profiling 的系统，该系统主要应用携带光可剪切linker的捕获探针对感兴趣RNA及蛋白进行捕获，再应用微调至的紫外光形成ROI（1-5000个细胞）进行光裂解，再逐一收取对应空间位置的靶标信息进行NGS测序分析。此系统具有了ROI的空间分辨率，分别实现了44种蛋白和96种基...
进一步在2020年他们推出了一种GeoMx™ Digital Spatial Profiling 的系统,该系统主要应用携带光可剪切linker的捕获探针对感兴趣RNA及蛋白进行捕获,再应用微调至的紫外光形成ROI(1-5000个细胞)进行光裂解,再逐一收取对应空间位置的靶标信息进行NGS测序分析。此系统具有了ROI的空间分辨率,分别实现了44种蛋白和96种基因的...
与基于原位成像的空间转录组相比，基于空间捕获阵列芯片与NGS的空间转录组技术，方法简单易实施，能够进行无偏的全转录组捕获，获得一定读长的序列信息，但大多受限于低空间分辨率，捕获不能实现真正的单细胞分辨率，而且存在使用不灵活、成本高昂等问题。为建立一个开源、灵活、灵敏的基于测序的空间转录组学平台，比利时弗...
Noninvasive prenatal testing (NIPT) analyzes cell-free DNA from a maternal blood sample to screen for common chromosomal conditions as early as the first trimester.
The NGS-based RNA-sequencing industry is projected to grow from USD 2.5 billion in 2022 and to reach USD 5.5 billion by 2027, at a Compound Annual Growth Rate (CAGR) of 17.2% during the forecast period.
Current Valuation:As of 2022, the NGS-based RNA-sequencing market size is estimated to be around USD 2.5 billion. Growth Projections:The market is expected to grow at a compound annual growth rate (CAGR) of approximately 17.2% from 2022 to 2027, potentially reaching USD 5.5 billion by 2027....
NGS-based liquid-biopsy profiling identifies mechanisms of resistance to ALK inhibitors: a step towards personalized NSCLC treatmentALK-TKIEML4-ALKLiquid BiopsyNGSNSCLCDespite impressive and durable responses, non﹕mall cell lung cancer (NSCLC) patients treated with anaplastic lymphoma kinase inhibitors (...
NGS-based virus testing, a preferred approach to mitigating the virus contamination risk While advanced therapy medicinal products (ATMPs) represent a promising new generation of treatments, they are more vulnerable to viral contaminations that could go undetected by standard methods compared to well...
Fig. 1. Overall scheme for NGS-based deep bisulfite sequencing. (A) The entire procedure of the NGS-based deep bisulfite sequencing protocol is shown as a flowchart. (B) The adaptor ligation step for the current protocol has adopted one strategy, in which the added PCR products an...
DNA-based NGS检测基因融合灵敏度、特异性较高,可满足大部分肿瘤患者需求 一项基于DNA-based NGS panel的大样本回顾性研究分析显示,基于DNA-based NGS检测NTRK融合具有81.1%的总体敏感性和99.9%的特异性,证明了DNA-based NGS对NTRK融合进行检测是可行的。...