3. Davies KD, Le AT, Sheren J, et al., Comparison of Molecular Testing Modalities for Detection of ROS1 Rearrangements in a Cohort of Positive Patient Samples. J Thorac Oncol. 2018 Oct;13(10):1474-1482. 4. Marc
NGS-Based Viral Safety Testing for ATMPs: Mandatory or Just an Option? NGS-based virus testing, a preferred approach to mitigating the virus contamination risk While advanced therapy medicinal products (ATMPs) represent a promising new generation of treatments, they are more vulnerable to viral...
New EuroGentest/ESHG guidelines and a new clinical utility gene card format for NGS-based testing. Eur J Hum Genet 2016;24:1.Matthijs G, Dierking A, Schmidtke J. New EuroGentest/ESHG guidelines and a new clinical utility gene card format for NGS- based testing. Eur J Hum Genet. ...
Noninvasive prenatal testing (NIPT) analyzes cell-free DNA from a maternal blood sample to screen for common chromosomal conditions as early as the first trimester.
PathoQuest provides biosafety assays based on next-generation sequencing (NGS) for biologics quality testing. GMP biotesting for biopharmaceuticals. Learn more.
The aim of this study was to assess the frequency of mismatch repair deficiency (MMR-D)/microsatellite instability (MSI) in 400 cases of non-endometrioid ovarian tumors (high-grade serous, low-grade serous, mucinous and clear cell), to compare different methodological approaches of testing, and...
A quality assurance program is an integral part of clinical laboratory operations, in particular for laboratories that are adopting new technologies to provide state-of-the-art genetic testing services. In this chapter, we describe the steps taken in implementation of test validation and quality ...
We aim to close above- mentioned technical knowledge gaps by optimizing six key steps through comparative experimental testing (Q#1-6; detailed in Fig. 1). We introduce a refined wet-lab strategy together with an open-source cfDNA pathogen identification workflow, referred to as cell-free DNA ...
Noninvasive prenatal testing (NIPT) analyzes cell-free DNA from a maternal blood sample to screen for common chromosomal conditions as early as the first trimester.
The purpose of this retrospective study is to explore the value of next-generation sequencing (NGS)- based preimplantation genetic testing for aneuploidy (PGT-A) of trophectoderm biopsy in the clinical outcomes for RIF patients with advanced age. A total of 265 RIF patients, who underwent 346 ...