[8]Testing for ESR1 Mutations to Guide Therapy for Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer: ASCO Guideline Rapid Recommendation Update. Journal of Clinical Oncology,2023. doi.org/10.1200/JCO.23. [9] 乳腺癌NCCN指南(2024 V1). ...
[7] Quality Management for Molecular Genetic Testing; Approved Guideline MM20-A [8] Comparison of immunohistochemistry with fluorescence in situ hybridization in determining the human epidermal growth factor receptor 2 status of breast cancer specimens: a multicenter study of 3 149 Chinese patients. C...
In contrast to NSCLC, "there is currently no need to perform tumor multigene NGS for patients with mBC [metastatic breast cancer] in the context of daily practice," ESMO states. This is largely because somatic sequencing cannot fully substitute germline testing forBRCAstatus, and other mutations,...
Vance GH, Viale G, McShane LM, Dowsett M. Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Focused Update
[1] Wolff AC, Hammond MEH, Allison KH, Harvey BE, Mangu PB, Bartlett JMS, Bilous M, Ellis IO, Fitzgibbons P, Hanna W, Jenkins RB, Press MF, Spears PA, Vance GH, Viale G, McShane LM, Dowsett M. Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society ...
Molecular subtyping and genomic profiling expand precision medicine in refractory metastatic triple-negative breast cancer: the FUTURE trial Journal:Cell Research IF:17.848 PMID:32719455 概要: 三阴性乳腺癌(TNBC)是高度异质性疾病,分子亚型可能会改善精确诊断和靶向治疗。复旦团队之前的研究将TNBCs分为具有潜在治...
Hope S. Rugo, MD:That leads us into the idea of NGS [next-generation sequencing] and when we should be doing NGS and in what patient. Tiffany, do you do NGS testing on all of your patients with triple-negative breast cancer [TNBC] in the metastatic setting?
Everyone knows about BRCA testing in breast cancer; there's EGFR, there are biomarkers that predict benefit from immunotherapy, and in brain cancer, there's IDH1. The IDH1 story is really compelling because now we can stratify the patients who are long-term survivors in the dreaded disease of...
Conditions such as Li-Fraumeni, Cowden, Peutz-Jeghers, and hereditary diffuse gastric cancer (HDGC) syndromes have been associated with a significantly increased risk for breast cancer, and genetic testing of the genes associated with these conditions (i.e.,TP53,PTEN,STK11andCDH1) has been an ...
Assessing the value of repeat next generation testing in patients with non-small cell lung cancer: A retrospective review. 3071#Background:Analyzing a tumor's molecular profile in non-small cell lung cancer (NSCLC) by next generation sequencing (NGS) has been essential in the a... B Warnecke...