8. Singhi AD, Liu T-C, Roncaioli JL, et al. Alternative lengthening of telomeres and loss of DAXX/ATRX expression predicts metastatic disease and poor survival in patients with pancreatic neuroendocrine tumors.
荧光原位杂交(FISH)是检测 MET 扩增的金标准,而中国患者中关于二代测序(NGS)检测 MET 扩增表现的数据有限。近日,Lung Cancer发表一项四川大学华西医院的研究,以 FISH 为参照,评估了 EGFR TKI 耐药患者中 NGS 检测组织和血浆样本 MET 扩增的...
在后期的LIBRETTO-321研究中,入组的1名RET融合TC初治患者,接受了23.4周治疗,并在第8周疗效评估达到PR,最大肿瘤负荷缩小43%,至试验数据截止时,缓解仍在持续。 图9 LIBRETTO-001临床试验疗效评估另外,今年发表在HEAD AND NECK CANCER期刊上的研究总结了甲状腺癌不同通路基因变异的靶向治疗方案和作用机理[9],除了普...
NGS methods for cancer research Selecting an appropriate NGS method for a research project can be overwhelming due to the rapidly growing variety of methods and the large amounts of complex information generated in NGS experiments. To narrow the choice of...
8. Locke WJ, et al. DNA Methylation Cancer Biomarkers: Translation to the Clinic.Front Genet. 2019 Nov 14;10:1150. 9. Vivek Kumar, et al. (2019) Techniques/Tools to Study Epigenetic Biomarkers in Human Cancer Detection Biomedical Engineering and its Applications in Healthcare pp 327-351 ...
[8] Comparison of immunohistochemistry with fluorescence in situ hybridization in determining the human epidermal growth factor receptor 2 status of breast cancer specimens: a multicenter study of 3 149 Chinese patients. Chin Med J 2014;127 (2): 246-253 ...
另外,今年发表在HEAD AND NECK CANCER期刊上的研究总结了甲状腺癌不同通路基因变异的靶向治疗方案和作用机理[9],除了普拉替尼和塞普替尼之外,包括凡德他尼,卡博替尼,培唑帕尼、舒尼替尼等多靶点抑制剂能为RET基因变异的患者带来获益可能。 图10 甲状腺癌靶向治疗和作用机理甲状腺基因检测,除了RET基因之外,还有多个驱...
[3].Heather A. Wakelee, et al.,IMpower010: Primary results of a phase III global study of atezolizumab versus best supportive care after adjuvant chemotherapy in esected stage IB-IIIA non-small cell lung cancer (NSCLC). 2021 ASCO, abs 8500. ...
9. Vivek Kumar, et al. (2019) Techniques/Tools to Study Epigenetic Biomarkers in Human Cancer Detection Biomedical Engineering and itsapplications in Healthcare pp 327-351 10. Frommer, M., et al. (1992). A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues...
They have led to the creation of The Cancer Genome Atlas (TCGA) (2), a database of molecular changes in multiple diverse cancer types, and the Pan Cancer Atlas, a reference library of key publications on cancer cell-of-origin patterns, oncogenic ...