Steven N. Kalkanis, MD, explains how next-generation sequencing testing fits into cancer treatment today and efforts that need to be made to enable its widespread use in the future. Steven N. Kalkanis, MD Steven N. Kalkanis, MD Next-generation sequencing (NGS) is the future of oncology,...
NGS testing is already used extensively in oncology, particularly in metastatic cancer, she noted. The technology is used to assess the sequence of DNA in genes from a tumor tissue sample. Numerous genes can be quickly sequenced at the same time at relatively low cost. The results provide info...
Cancer is predominantly driven by somatic mutations, which can occur at any level in a sample because of tumor heterogeneity caused by co-existence of multiple mutations in the tumor cell or occurrence of multiple cancerous clones in the same tumor. Consequently, it is challenging to defi...
e18563#Background:Next Generation Sequencing (NGS) testing is gradually becoming an essential aspect of cancer care. However, numerous studies have shown that non-White patients are under-represented in both precision oncology clinical trials and molecular testing. Highland General Hospital (HGH) is ...
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[17] Socinski M A, Pennell N A, Davies K D. MET Exon 14 Skipping Mutations in Non-Small-Cell Lung Cancer: An Overview of Biology, Clinical Outcomes, and Testing Considerations[J]. JCO precision oncology, 2021, 5: PO.20.00516.
然而,现存多个会影响NGS在临床实践中成功率的因素,临床医生需要在临床实践中充分了解NGS的优劣势以及实施NGS时需要考虑的问题,基于此,来自意大利的Giovanna De Maglio等人在Critical Reviews in Oncology / Hematology[1]上发表了一篇题为“The storm of NGS in NSCLC diagnostic-therapeutic pathway: How to sun the ...
然而,现存多个会影响NGS在临床实践中成功率的因素,临床医生需要在临床实践中充分了解NGS的优劣势以及实施NGS时需要考虑的问题,基于此,来自意大利的Giovanna De Maglio等人在Critical Reviews in Oncology / Hematology[1]上发表了一篇题为“The storm of NG...
[10] Monaghan KG, Zehnbauer B, Booker JK,et al. Molecular Methods for Clinical Genetics and Oncology Testing ;Approved Guideline-Third Edition[ EB/OL]. (2012-5-18 )[2017-12-20].https://clsi. org/media/1486/mm01a3_sample. pdf. ...