摘要 NF-kBinducing kinase (NIK), which is essential for the activation of the noncanonical NF-kB pathway, regulates diverse processes in immunity, development, and disease. Although recent studies have elucidated important functions of NIK in adaptive immune cells and cancer cell metabolism, the rol...
Nuclear factor-KB (NF-KB) and activator protein 1 (AP-1) are well-characterized ubiquitously expressed transcription factors that play important roles in the response to cellular stress situations. In unstimulated resting cells, NF-KB and AP-1 are inacti
ＮＦ—ＫＢ对ＴＮＦ—ａ基因转录的调控及其与两型ＴＮＦ一Ⅸ生物学功能的相互影响 全文摘要 ／ ｆ肿瘤坏死因子一ａ（ｔｕｍｏｒｎｅｃｒｏｓｉｓｆａｃｔｏｒ一Ⅸ，ＴＮＦ—ａ）是一种具有广泛生物学功能的细胞因子，其基因的表达受核因子一ｎＢ（ｎｕｃｌｅａｒｆａｃｔｏｒ－Ｋ）？ｒＴ－ＮＦ—ＫＢ）的调节。同...
Studies previously showed that salmon trypsin increases transcriptional activity of NF-B and induces secretion of IL-8 from airway epithelial cells by activating PAR-2. The aim of this study was to explore if purified trypsins from king crab (Paralithodes camtschaticus) and sardine (Sardinops ...
The research interest in NF-κB revolves around its potential therapeutic targets. Scientists are exploring the canonical and non-canonical pathways to inhibit this complex, as it is central to regulating immune and inflammatory responses. In the last decade, there has been a significant ...
TheRolesofNF-kBandG(n)sR,gulationofC,llsApoptosisAft,rTraumaticBrainInjury ZHAOHong(n)anl(YANGKa)(m)ng2 (l)Neuroiog,caiDepartmentofAff(i)atedHosp,taiofDai(Un)vers(ty)Dai,,Yunnan67l000(Ch)na; 2(Anatom)cDepartmentofPreci(n)caiMed,caiCoiiege(Dai)Un(vers)ty(Dai),Yunnan67l000(Ch)na>...
A20, a zinc finger protein, is induced by NF-kB activators. A20 acts as a negative regulator, preventing TRAF2 from further activating NF-kB, and it also inhibits TNF and IL-1-induced NF-kB activation, indicating its potential as a general inhibitor of NF-kB signaling.
摘要: Studies the oxidant-sensitive and phosphorylation-dependent activation of NF-KB and A-1 in endothelial cells. Cell culture; Gel mobility shift assays; Dose and time relationships for oxidant-induced transacting factor levels; Role of tyrosine kinases and phosphatases in oxidant-induced effects....
Together with Snail1, the p65 subunit of NF-kB and PARP1 bound to the FN1 promoter. We detected nuclear interaction of these proteins and demonstrated the requirement of all three for FN1 transcription. Moreover, other genes involved in cell movement mimic FN1 expression induced by Snail1 ...
RIG-I knockout has been verified by functional assays and DNA sequencing. The stability of this cell line for 20 passages following thawing has been verified. A549-Dual™KO-RIG-I cells are guaranteed mycoplasma-free. Back to the top