因此,作为抗癌治疗的靶标,NF-κB是制药公司中许多活跃研究的主题。 今天,以文章“lncRNA-PLACT1 sustains activation of NF-κBpathway through a positive feedback loopwith IκBα/E2F1 axis in pancreatic cancer”为例,了解NF-κB信号通路在胰腺癌中的发挥...
Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis Mol Cancer(IF :46) 研究结果表明,抑制UbcH5c是治疗胰腺癌的一种新而有效的策略,DHPO代表了一类新的UbcH5c抑制剂,抑制UbcH5c介导的IκBα降解和NF-κB活化,这对其抗癌活性至关重要...
Cartwright, T.; Perkins, N.D.; Wilson, C.L. NFKB1: A suppressor of inflammation, ageing and cancer. FEBS J. 2016, 283, 1812-1822. [CrossRef] [PubMed]Cartwright T, Perkins ND, L Wilson C. NFKB1: a suppressor of inflammation, ageing and cancer. FEBS J. 2016;283:1812-22. [...
摘要 NF-kBinducing kinase (NIK), which is essential for the activation of the noncanonical NF-kB pathway, regulates diverse processes in immunity, development, and disease. Although recent studies have elucidated important functions of NIK in adaptive immune cells and cancer cell metabolism, the rol...
[5] Magne N,Toillon RA, Bottero V, et al. NFkappaB modu-lation and ionizing radiation : mechanisms and future direc tions for cancer treatment[Jl. Cancer, 2006 , 231 (2) : 158- 168. [6] Scheidereit C. IkappaB kinase complexes : gateways to NF- kappaB activation and transc[x]rip...
(Moles A, Butterworth JA, Sanchez A, et al. A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-κB-dependent liver regeneration and cancer.Oncogene. 2016;35(35):4623-4632. doi:10.1038/onc...
NF-κB; NFKB1; p105/p50; Bcl-3; cancer; inflammation; apoptosis1. Introduction One of the emerging questions in cancer biology is: “How are inflammation and dysregulated immune responses linked to cancer?” It is now widely accepted that chronic inflammation and infection represent major risk ...
of NF-κB signaling in inflammation and cancer. Mol Cancer. 2013;12:86. Published 2013 Aug 2.5. Beinke S, et al. Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J. 2004;382(Pt 2):393-409.6. Giridharan S, Srinivasan M. Mechanisms of NF-κB p65 and ...
Deka K, Li Y. Transcriptional Regulation during Aberrant Activation of NF-κB Signalling in Cancer. Cells. 2023;12(5):788. Published 2023 Mar 2. doi:10.3390/cells12050788 Tas SW, Bryant VL and Cook MC (2023) Editorial: Non-canonical NF-κB signaling in immune-mediated inflammatory diseases ...
[1] Karin M.NF-kappa B and cancer:mechanisms and targets[J].Mol Carcinog,2006,45(6):355-361. [2] Aranha MM,Borralho PM,Ravasco P,et al.NF-kappa B and apoptosis in colorectal tumourigenesis[J].Eur J Clin Invest,2007,37(5):416-424. ...