3,Targe ting the NF -kB Pathway inCancer Therapy.Derek J. Erstad,MDa, James C. Cusack Jr,MDb,(2013) 705–746 公众号已经建立实名“德兰系肿瘤免疫精英阅读荟”交流微信群,可以添加小编微信扫二维码拉进群,添加时请主动注明姓名、企业、职位。
因此,作为抗癌治疗的靶标,NF-κB是制药公司中许多活跃研究的主题。 今天,以文章“lncRNA-PLACT1 sustains activation of NF-κBpathway through a positive feedback loopwith IκBα/E2F1 axis in pancreatic cancer”为例,了解NF-κB信号通路在胰腺癌中的发挥...
Zhang X, Zhang Y, Zhou P, et al. Down-regulated cylindromatosis enhances NF-κB activation and aggravates inflammation in HBV-ACLF patients. Emerg Microbes Infect. 2022;11(1):1586-1601. doi:10.1080/22221751.2022.2077128 Role and mechanisms of the NF-ĸB signaling pathway in various developm...
[4]. Sun, S., The non-canonical NF-κB pathway in immunity and inflammation. Nature Reviews Immunology, 2017. 17(9): p. 545-558.[5]. Taniguchi, K. and M. Karin, NF-kappaB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol, 2018. 18(5): p. 309-324.[6]. Wa...
[18] Sun Y, St Clair DK, Fang F, et al. The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factorkappaB inhibition and enhanced by the presence of PTEN [Jl.Mol Cancer Ther, 2007, 6 (9) : 2477-2486. ...
κbsignalingpathwayandtheexpressionofnf-κb-regulateddrug-resistantgenes.molmedrep13(1):153-59.9.u.s.patentno.4,272,535.10.internationalapplicationno.pct/us2007/074233.11.ouyang,l.,etal.(2012).programmedcelldeathpathwaysincancer:areviewofapoptosis,autophagyandprogrammednecrosis.cellprolif.45:487-98.12....
SARS-CoV-2, liver disease, and cancer demonstrating the versatility of NF-κB research. High-impact papers like "Collagenolysis-dependent DDR1 signaling in pancreatic cancer" and "Targeting UbcH5c for pancreatic cancer treatment" showcase the translational potential of NF-κB pathway ...
The canonical pathway is triggered by numerous extracellular and intacellular signals such as proinflammatory cytokines (tumor necrosis factor α and interleukin-1), inflammatory signals such as bacterial lipopolysaccharide, Toll-like receptors and antigen receptors. These stimuli result in the activation ...
Study found that TLR4-MyD88-NF-κB signalling pathway plays an important role in the regulation of liver immune abnormalities,inflamma?tory response triggered by the liver damage,activation of hepatic stellate cells and liver fibrosis deterioration and the development of cancer of ...
29、al cells: Importance in IL-8 transcription Pulm Phannacol Ther, 2013, 26 : 318 -324.Sha Mt Ye J, Zhang L, et al Celastrol induces apoptosis of gastric cancer cells by miR 146a inhibition of NF-kappaB activity Cancer Cell Ini, 20139 13 : 50.NF-k B信号通路与炎症反应戸方薮掘作者...