Furthermore, the results of rescue experiments showed that the HSP90 inhibitor plays a reducing role of HMGB1 and HMGB2 via the NF-KB signaling pathway. Conclusion The results of the present study determine a potential role of anti-HSP90 in melanoma cancer cell oncogenesis via modulating HMGB2...
Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis Mol Cancer(IF :46) 研究结果表明,抑制UbcH5c是治疗胰腺癌的一种新而有效的策略,DHPO代表了一类新的UbcH5c抑制剂,抑制UbcH5c介导的IκBα降解和NF-κB活化,这对其抗癌活性至关重要...
Glycolysis can generate ATP in greater quantities and at a faster rate than oxidative phosphorylation. Glucose is therefore an essential nutrient for cancer and normal proliferating cells. NF-kB coordinates many of the signals that drive cell activation and proliferation during immunity, inflammation, an...
However, reports on RIBE with relevance to cancer radiotherapy especially investigating the bidirectional and...doi:10.12659/MSM.909153Liying ZhangYali LuoZhiwei LuJinpeng HeYongqi LiuMed Sci MonitMedical Science Monitor International Medical Journal of Experimental & Clinical Research...
(Chen Y, Wang D, Peng H, et al. Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression.Mol Canc...
Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome Nature(IF:70.2) 肿瘤基质对胰腺导管腺癌生长和转移以及患者生存的不同影响是通过ColI-DDR1-NF-κB-NRF2线粒体生物发生途径介导的,该途径的靶向成分可提供治疗机会。 Su H, Yang F, Fu R, et al. Collagenolysis-dependent DDR1 sign...
In vivo, exosomes enriched in miR-1910-3p promoted the proliferation and migration of breast cancer cells. MiR-1910-3p downregulated myotubularin-related protein 3, activated the NF-κB and wnt/β-catenin signaling pathway...
SARS-CoV-2, liver disease, and cancer demonstrating the versatility of NF-κB research. High-impact papers like "Collagenolysis-dependent DDR1 signaling in pancreatic cancer" and "Targeting UbcH5c for pancreatic cancer treatment" showcase the translational potential of NF-κB pathway ...
[18] Sun Y, St Clair DK, Fang F, et al. The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factorkappaB inhibition and enhanced by the presence of PTEN [Jl.Mol Cancer Ther, 2007, 6 (9) : 2477-2486. ...
Cervical cancer remains one of the most common malignancy in women all of the world [1]. Human papillomavirus (HPV) infection highly heighten the risk of cervical cancer through encoding E6 and E7 viral oncoproteins and disturbing p53 signaling pathway [2]. HPV vaccines and cervical cancer screen...