NF-kappaB signaling pathway, inflammation and colorec- tal cancer. Cell Mol Immunol 2009; 6: 327-34.Wang S,Liu Z,Wang L,et al.NF-kappaB signaling pathway,inflammation and colorectal cancer. Cellular and molecular immunology . 2009Wang S,Liu Z,Wang L. NF-kappaB signaling pathway,inflammation...
3. Christian F, Carmody RJ, et al. The Regulation of NF-κB Subunits by Phosphorylation. Cells. 2016;5(1):12. Published 2016 Mar 18. 4. Hoesel B, Schmid JA. The complexity of NF-κB signaling in inflammation and cancer. Mol Cancer. 2013;12:86. Published 2013 Aug 2. 5. Beinke S...
3. Christian F, Carmody RJ, et al. The Regulation of NF-κB Subunits by Phosphorylation. Cells. 2016;5(1):12. Published 2016 Mar 18. 4. Hoesel B, Schmid JA. The complexity of NF-κB signaling in inflammation and cancer. Mol Cancer. 2013;12:86. Published 2013 Aug 2. 5. Beinke S...
Down-regulated cylindromatosis enhances NF-κB activation and aggravates inflammation in HBV-ACLF patients Emerging Microbes & Infections(IF:18) 研究发现下调的圆柱状瘤通过增强乙型肝炎病毒相关性急性慢性肝衰竭患者的NF-κB活化来加重炎性细胞趋化性,从而参与HBV-ACFL损伤的发病机制。 Zhang X, Zhang Y, Zho...
13. Taniguchi K, et al. NF-κB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol. 2018;18(5):309-324. 14. Erstad DJ, Cusack JC Jr. Targeting the NF-κB pathway in cancer therapy. Surg Oncol Clin N Am. 2013;22(4):705-...
TargetMolNF-κB信号通路分子库是由740 个 NF-κB信号通路相关的小分子化合物组成的独特集合，用于NF-κB信号通路相关的研究及药物的筛选，可用于高通量、高内涵筛选。化合物库组成：参考文献：1. Zhang T, Ma C, Zhang Z, Zhang H, Hu H. NF-κB signaling in inflammation and cancer. MedComm. 2021;2(4...
图3. TNFR1 介导的 NF-kB 激活[9] ■非经典 NF-κB 激活 受到特定 TNF 受体家族成员的刺激 (包括:LTβR,CD40,CD27,CD30,BAFF-R,RANK 等),这些成员通过募集 TRAF2 和 TRAF3 发出信号。 非经典途径中的上游激酶是 NF-κB 诱导激酶 (NIK)。如前面的图 2,pIKKα 对 p100 的磷酸化至关重要,导致蛋...
13. Taniguchi K, et al. NF-κB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol. 2018;18(5):309-324. 14. Erstad DJ, Cusack JC Jr. Targeting the NF-κB pathway in cancer therapy. Surg Oncol Clin N Am. 2013;22(4):705-746. ...
NF-κB 通路主要包括两种信号激活机制:经典途径(又称为 canonical pathway)和非经典途径(又称为 noncanonical pathway)。 Canonical and noncanonical pathwaysof NF-κB activation. 经典途径 主要响应于炎症、免疫反应等信号,其特点是依赖于 IκB激酶复合体(IKK)的激活,特别是 IKKβ 的活化,进而导致 IκB 的磷酸化...
et al. Activation of IKKa of a second, evolutionary conserved, NF-kB signaling pathway. Science 293, 1495–1499 (2001). This paper identifies IKK α as a NIK-target kinase that directly phosphorylates p100 to induce p100 processing. CAS PubMed Google Scholar Jin, W., Zhou, X. F., Yu...