NF—KB信号通路鱼类先天性免疫NF-KB signal pathway Fish Innate immune systemNF-KB(nuclearfactorKB)是一种广泛存在的核转录因子。经不同刺激信号激活后,参与多种免疫反应相关基因的表达调控,对鱼类先天性免疫调节起着十分重要的作用。对鱼类NF—KB的结构、功能及其信号传导途径进行概述,并对NF—KB信号通路在鱼类先...
7. Yu H, et al. Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study. Signal Transduct Target Ther. 2020;5(1):209. Published 2020 Sep 21. 8. Christian F, Carmody RJ, et al. The Regulation of NF-κB Subunits by...
NF-κB家族有由cRel,RelA(p65),RelB,NF-kB1(p50)、NF-kB2(p52)组成,它们在N端都具有Rel同源结构域,其中cRel,RelA(p65)和RelB存在转录激活区(TAD),可正向调节基因表达;p52和p50分别由前体蛋白p100、p105裂解而成,前体蛋白的C端有类似...
7. Yu H, et al. Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study. Signal Transduct Target Ther. 2020;5(1):209. Published 2020 Sep 21. 8. Christian F, Carmody RJ, et al. The Regulation of NF-κB Subunits by Phosphorylation. Cells. 2016;5(1):12. ...
RHD 结构域负责形成二聚体, 结合DNA 以及与I Bs 的结合, 同时它还含有核定位序列(nuclear localization signal, NLS,介导活化的NF-B 进入核内行使功能。p65 (RelA、RelB 、c-Rel 的C 端含有转录激活结构域(transactivation domain,TAD。这些TADs 可以和多种基本转录因子(basal transcriptionapparatus 相互作用, ...
7. Yu H, et al. Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study. Signal Transduct Target Ther. 2020;5(1):209. Published 2020 Sep 21. 8. Christian F, Carmody RJ, et al. The Regulation of NF-κB Subunits by Phosphorylation. Cells. 2016;5(1):12. ...
signaling pathways pathway NF- kB kappaB NF-kB Signaling Pathways 《NF-kBSignalingPathways》由会员分享,可在线阅读,更多相关《NF-kBSignalingPathways(2页珍藏版)》请在人人文库网上搜索。 1286 Cell 127, December 15, 2006 2006 Elsevier Inc. DOI 10.1016/j.cell.2006.12.005 See online version for legend...
7. Yu H, et al. Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study. Signal Transduct Target Ther. 2020;5(1):209. Published 2020 Sep 21. 8. Christian F, Carmody RJ, et al. The Regulation of NF-κB Subunits by Phosphorylation. Cells. 2016;5(1):12. ...
7. Yu H, et al. Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study. Signal Transduct Target Ther. 2020;5(1):209. Published 2020 Sep 21. 8. Christian F, Carmody RJ, et al. The Regulation of NF-κB Subunits by Phosphorylation. Cells. 2016;5(1):12. ...
7. Yu H, et al. Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study. Signal Transduct Target Ther. 2020;5(1):209. Published 2020 Sep 21. 8. Christian F, Carmody RJ, et al. The Regulation of NF-κB Subunits by Phosphorylation. Cells. 2016;5(1):12. ...