Explore the NFkB pathway and its impact on inflammation and immune responses. Click here to learn more about this signaling pathway.
NF-κB家族有由cRel,RelA(p65),RelB,NF-kB1(p50)、NF-kB2(p52)组成,它们在N端都具有Rel同源结构域,其中cRel,RelA(p65)和RelB存在转录激活区(TAD),可正向调节基因表达;p52和p50分别由前体蛋白p100、p105裂解而成,前体蛋白的C端有类似...
7. Yu H, et al. Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study. Signal Transduct Target Ther. 2020;5(1):209. Published 2020 Sep 21. 8. Christian F, Carmody RJ, et al. The Regulation of NF-κB Subunits by...
7. Yu H, et al. Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study. Signal Transduct Target Ther. 2020;5(1):209. Published 2020 Sep 21. 8. Christian F, Carmody RJ, et al. The Regulation of NF-κB Subunits by Phosphorylation. Cells. 2016;5(1):12. ...
Chen, Correlation of NF-kB signal pathway with tumor metastasis of human head and neck squamous cell carcinoma, BMC Cancer 10 (1) (2010) 437.Yan M, Xu Q, Zhang P & Zhou WJ. Correlation of NF- KB Signal Pathway With Tumormetastasis Of Human Head And Neck Squamous Cell Carcinoma. Bio ...
et al. Correlation of NF-κB signal pathway with tumor metastasis of human head and neck squamous cell carcinoma. BMC Cancer 10, 437 (2010). https://doi.org/10.1186/1471-2407-10-437 Download citation Received24 March 2010 Accepted17 August 2010 Published17 August 2010 DOIhttps://doi.org/...
IκB kinase is an essential component of the Tpl2 signaling pathway. Mol. Cell Biol. 24, 6040–6048 (2004). 94. Bouwmeester, T. et al. A physical and functional map of the human TNF-α/NF-κB signal transduction pathway. Nat. Cell Biol. 6, 97–105 (2004). 95. Ferrier, R. et...
Role of NF-κB Signal Pathway in the Innate Immune System of Fish 暂未订购 下载PDF 引用 收藏 分享 摘要 NF-κB(nuclear factorκB)是一种广泛存在的核转录因子。经不同刺激信号激活后,参与多种免疫反应相关基因的表达调控,对鱼类先天性免疫调节起着十分重要的作用。对鱼类NF-κB的结构、功能及其信号传导...
Cell. Signal. 18, 1309–1317 (2006). CAS PubMed Google Scholar Senftleben, U. et al. Activation of IKKa of a second, evolutionary conserved, NF-kB signaling pathway. Science 293, 1495–1499 (2001). This paper identifies IKK α as a NIK-target kinase that directly phosphorylates p100 ...
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