Down-regulated cylindromatosis enhances NF-κB activation and aggravates inflammation in HBV-ACLF patients Emerging Microbes & Infections(IF:18) 研究发现下调的圆柱状瘤通过增强乙型肝炎病毒相关性急性慢性肝衰竭患者的NF-κB活化来加重炎性细胞趋化性,从而参与HBV-ACFL损伤的发病机制。 Zhang X, Zhang Y, Zho...
NF-κB家族有由cRel,RelA(p65),RelB,NF-kB1(p50)、NF-kB2(p52)组成,它们在N端都具有Rel同源结构域,其中cRel,RelA(p65)和RelB存在转录激活区(TAD),可正向调节基因表达;p52和p50分别由前体蛋白p100、p105裂解而成,前体蛋白的C端有类似...
[4]. Sun, S., The non-canonical NF-κB pathway in immunity and inflammation. Nature Reviews Immunology, 2017. 17(9): p. 545-558.[5]. Taniguchi, K. and M. Karin, NF-kappaB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol, 2018. 18(5): p. 309-324.[6]. ...
NF-κB 通路主要包括两种信号激活机制:经典途径(又称为 canonical pathway)和非经典途径(又称为 noncanonical pathway)。 Canonical and noncanonical pathwaysof NF-κB activation. 经典途径 主要响应于炎症、免疫反应等信号,其特点是依赖于 IκB激酶复合体(IKK)的激活,特别是 IKKβ 的活化,进而导致 IκB 的磷酸化...
13. Taniguchi K, et al. NF-κB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol. 2018;18(5):309-324. 14. Erstad DJ, Cusack JC Jr. Targeting the NF-κB pathway in cancer therapy. Surg Oncol Clin N Am. 2013;22(4):705-...
The Nuclear Factor NF-kB Pathway in Inflammation.Lawrence, Toby
The non-canonical NF-κB pathway is involved in various inflammatory diseases, such as rheumatoid arthritis, systemic lupus erythematosus, kidney inflammation and injury, metabolic inflammation, and central nervous system inflammation. Abstract The nuclear factor-κB (NF-κB) family of transcription factor...
13. Taniguchi K, et al. NF-κB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol. 2018;18(5):309-324. 14. Erstad DJ, Cusack JC Jr. Targeting the NF-κB pathway in cancer therapy. Surg Oncol Clin N Am. 2013;22(4):705-746. ...
NF-κB appears to mediate renal inflammation in different cell types, including renal cells, innate immune cells, and lymphocytes. It is thus clear that targeting NF-κB signaling pathway represents an attractive therapeutic approach in renal disease treatment. However, global inhibition of NF-κB ...
NFκB-related Assays (Inflammation)Synonyms LightSwitch, Light Switch, GoClone, Go Clone, reporter assay, reporter gene, luciferase reporter, Renilla luciferase, RenSP, validated pathway assay, biomarker sets, NFkB, Inflammation, CD40, IL8, VCAM1, CSF1, NFKB2, RELB, TNFAIP3, IRF1, NFKB10-...