NF-κB家族有由cRel,RelA(p65),RelB,NF-kB1(p50)、NF-kB2(p52)组成,它们在N端都具有Rel同源结构域,其中cRel,RelA(p65)和RelB存在转录激活区(TAD),可正向调节基因表达;p52和p50分别由前体蛋白p100、p105裂解而成,前体蛋白的C端有类似...
13. Taniguchi K, et al. NF-κB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol. 2018;18(5):309-324. 14. Erstad DJ, Cusack JC Jr. Targeting the NF-κB pathway in cancer therapy. Surg Oncol Clin N Am. 2013;22(4):705-746. 15. Martin M, Lu T et al. The ...
13. Taniguchi K, et al. NF-κB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol. 2018;18(5):309-324. 14. Erstad DJ, Cusack JC Jr. Targeting the NF-κB pathway in cancer therapy. Surg Oncol Clin N Am. 2013;22(4):705-746. 15. Martin M, Lu T et al. The ...
[3]. Czerkies, M., et al., Cell fate in antiviral response arises in the crosstalk of IRF, NF-κB and JAK/STAT pathways. Nature Communications, 2018. 9(1).[4]. Sun, S., The non-canonical NF-κB pathway in immunity and inflammation. Nature Reviews Immunology, 2017. 17(9): p. ...
13. Taniguchi K, et al. NF-κB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol. 2018;18(5):309-324. 14. Erstad DJ, Cusack JC Jr. Targeting the NF-κB pathway in cancer therapy. Surg Oncol Clin N Am. 2013;22(4):705-...
13. Taniguchi K, et al. NF-κB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol. 2018;18(5):309-324. 14. Erstad DJ, Cusack JC Jr. Targeting the NF-κB pathway in cancer therapy. Surg Oncol Clin N Am. 2013;22(4):705-746. ...
13. Taniguchi K, et al. NF-κB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol. 2018;18(5):309-324. 14. Erstad DJ, Cusack JC Jr. Targeting the NF-κB pathway in cancer therapy. Surg Oncol Clin N Am. 2013;22(4):705-746. ...
Zhang X, Zhang Y, Zhou P, et al. Down-regulated cylindromatosis enhances NF-κB activation and aggravates inflammation in HBV-ACLF patients. Emerg Microbes Infect. 2022;11(1):1586-1601. doi:10.1080/22221751.2022.2077128 Role and mechanisms of the NF-ĸB signaling pathway in various developm...
NF-κB 通路主要包括两种信号激活机制:经典途径(又称为 canonical pathway)和非经典途径(又称为 noncanonical pathway)。 Canonical and noncanonical pathwaysof NF-κB activation. 经典途径 主要响应于炎症、免疫反应等信号,其特点是依赖于 IκB激酶复合体(IKK)的激活,特别是 IKKβ 的活化,进而导致 IκB 的磷酸化...
13. Taniguchi K, et al. NF-κB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol. 2018;18(5):309-324. 14. Erstad DJ, Cusack JC Jr. Targeting the NF-κB pathway in cancer therapy. Surg Oncol Clin N Am. 2013;22(4):705-746. ...