NF-κB家族成员 NF-κB家族有由cRel,RelA(p65),RelB,NF-kB1(p50)、NF-kB2(p52)组成,它们在N端都具有Rel同源结构域,其中cRel,RelA(p65)和RelB存在转录激活区(TAD),可正向调节基因表达;p52和p50分别由前体蛋白p100、p105裂解而成,前体...
Su H, Yang F, Fu R, et al. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer...
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Gualou xiebai decoction ameliorates cardiorenal syndrome type II by regulation of PI3K/AKT/NF-κB signalling pathway 背景 II型心肾综合征(CRS2)是一种多器官疾病,表现为心肾功能障碍的综合征,由慢性心功能不全导致慢性肾脏疾病。它影响着全世界至少2600万人,而且其流行率正在上升。瓜蒌薤白汤GXD是一种在冠心...
Shikonin causes cell-cycle arrest and induces apoptosis by regulating the EGFR-NF-kappa B signalling pathway in human epidermoid carcinoma A431 cells[J]. Biosci Rep, 2015, 35(2): e00189. [24] Yang HF, Sun RQ, Ma N, et al. Inhibition of nuclear factor-kappa B signal by pyrrolidine...
The NF‐κB signalling pathway in osteoarthritis. Int J Biochem Cell Biol. 2013;45:2580‐2584.Rigoglou, S., & Papavassiliou, A. G. (2013). The NF-kappaB signalling pathway in osteoarthritis. Int J Biochem Cell Biol, 45(11), 2580-2584....
1、生理科学进展20】4年第45卷第】期 #NFkB信号通路与炎症反应王晓晨吉爱国(山东大学威海国际生物技术研发中心,威海264209)摘要 核转录因子kappaB(NF-KB)是细胞中重要的转录调节因子,通常以P50-p65异二聚体的形 式与其抑制性蛋白(inhibitor kappaB, IkB)结合而呈非活化状态。NF-kB通过剌激因子(病毒、肿 瘤坏死...
一篇发表在《Phytomedicine》杂志,名为“Gualou xiebai decoction ameliorates cardiorenal syndrome type II by regulation of PI3K/AKT/NF-κB signalling pathway”的文章,旨在评估GXD乙醇提取物对CRS2的影响,阐明其在心肌梗死模型中的潜在机制,为CRS2的临床治疗提供一个潜在的靶点。
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NF-kB Signaling Pathways 1286 Cell 127, December 15, 2006 ©2006 Elsevier Inc. DOI 10.1016/j.cell.2006.12.005 See online version for legend and references.S n a p S h o t : N F k B S i g n a l i n g P a t h w a y s M ...