参考文献: [l] Deorukhkar A,Krishnan S. Targeting inflammatory path- ways for tumor radiosensitization[Jl. Biochem Pharma- col, 2010 ,80(12) :1904-1914. [2] Roshak AK,Callahan JF, Blake SM. Small-molecule inhib-itors of NF-kappaB for the treatment of inflammatory joint disease [Jl. Cur...
Effects of acupuncture on the expression and content of nuclear factor- κB and tumor necrosis factor-α in rat brain after cerebral ischemia / reperfusion [J]. Chinese Journal of Rehabilitation Medicine),2009,24(8):711-714.电针对脑缺血大鼠NF-κB及TNF-α表达的影响[J]. 孔立红,刘胜洪,毛娟娟...
whi ay provide a theory basis for research of macrophage polarization . [Key words ] Macrophage; Polarization; Regulation , 和CD80 识别 促炎介质肿瘤坏死因子( tumor 最早期对巨噬细胞极化的描述为 当机体受到 T , necrosis factor ,TNF) - 、 ( IL)-12、IL-6 , 外界刺激进行 细胞应答时 招募的巨...
X ta n 7 1{)06 1 ,C hi na A bstract: Obj ective T o study the expression and significance of nuclear transcription factor xB( NF-~B ) and tumor suppr essor gene p53 protein in breast ca ncer.M ethods Immunohistochemical stai ni ng w as used tO detect t he ex pr ession of ...
NF-kB是 一可诱 导的 DNA结合 固子 ,它 除了是 k基 因的激 活者外 尚对 众多的 细胞、 病 毒基因有调 节 作用 ,并编绅 许多与 免疫功 能 、炎症相 关的蛋 白,如 I类主要 组织相容性 抗原、微球 蛋白 陟、白细胞介紊一6(interlukin—B tL-6~、肿瘤坏死因子一a(tumornecro~is factor—a ...
[11]Yan M,Xu Q,Zhang P,et al.Correlation of NF-kappaB signalpathway with tumor metastasis of human head and neck squamouscell carcinoma[J].BMC Cancer,2010,10(1):437-449. [12]Conti A,Cardali S,Genovese T,et a1.Role of inflammation in the secondary injury following experimental spinal ...
ＮＦ—ＫＢ对ＴＮＦ—ａ基因转录的调控及其与两型ＴＮＦ一Ⅸ生物学功能的相互影响 全文摘要 ／ ｆ肿瘤坏死因子一ａ（ｔｕｍｏｒｎｅｃｒｏｓｉｓｆａｃｔｏｒ一Ⅸ，ＴＮＦ—ａ）是一种具有广泛生物学功能的细胞因子，其基因的表达受核因子一ｎＢ（ｎｕｃｌｅａｒｆａｃｔｏｒ－Ｋ）？ｒＴ－ＮＦ—ＫＢ）的调节。同...
Tumor necrosis factor (TNF), a well-studied activator, initiates the process by binding to its receptor and recruiting TNF receptor death domain (TRADD). TRADD, in turn, binds to TNF receptor-associated factor 2 (TRAF-2), which then attracts NF-kB-inducible kinase (NIK). Both ...
目的:肿瘤坏死因子α(tumor necrosis factor,TNF-α)是调节细胞生长,分化,诱发炎症并调控细胞凋亡的细胞因子之一.核因子-kB(nuclear transcriptionfactor-kappa B, NF-kB)是一个重要的核转录因子,在肝细胞,HSCs,内皮细胞中都能检测到其表达,核因子-kB具有多向性的调节作用,可以调控多种细胞因子的转录,阻止HSCs的凋...
factorK B) 核因子K (nuclearB,NF-K 转录因子V factor) (transcription 羟脯氨酸。 (Hydroxyproline) necrosis 辨瘙餐死四予0(tumor factor,TNF—d) 交气管肺泡灌洗液J (Bronchoalveolarfluid) lavage 甲基强的松龙1 (methyIprednisonlone) , 威义寡核瞽酸。(antisense oligonucleotides) Theeffect0f B in ...