Regulation of NF-kappa B and disease control: identification of a novel serine kinase and thioredoxin as effectors for signal transduction pathway for NF-... T Okamoto,S Sakurada,JP Yang,... 被引量: 0发表: 0年 [Current Topics in Cellular Regulation] Volume 35 || Regulation of NF-κB and...
The chronic inflammatory bowel diseases (IBD), such as Crohn's disease (CD) and ulcerative colitis (UC), are multifactorial pathologies. There is overwhelming evidence that genetic factors play a pivotal role in the predisposition to suffer from IBD. The severity of the inflammatory response depend...
Strong nuclear factor-kappa B-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in spo- radic Alzheimer's disease superior temporal lobe... Walter J. Lukiw,Nicolas G. Bazan - 《Journal of Neuroscience Research》 被引量: 70发表: 2015年 Oxidative stress-dependent changes in ...
The purpose of this study was to identify critical pathways promoting survival of tamoxifen-tolerant, estrogen receptor alpha positive (ER+) breast cancer cells, which contribute to therapy resistance and disease recurrence. Gene expression profiling and pathway analysis were performed in ER+ breast tum...
A role for neuronal NF-κB in suppressing neuroinflammation and promoting neuroprotection in the CNS. Nuclear factor-κB ( NF-κB ) signaling plays a crucial role during inflammatory, demyelinating disease and that becomes evident through opposing proinflam... M Emmanouil,E Taoufik,V Tseveleki,....
英文: Expression of transcription factor AP-1 and NF-kappaB in anergic T cells中文: AP-1与NF-κB的活化表达与T细胞的无能 英文: NF-κB and disease中文: NF-κB与疾病 英文: The NF-κB Signal Pathway of Insects中文: 昆虫的NF-κB信号通路 ...
Thus, ADMA seems to be the culprit, and not just an innocent biochemical bystander, of the atherosclerotic disease process. Moreover, reduced NO ... D Fliser,JT Kielstein,H Haller,... - 《Kidney International》 被引量: 382发表: 2003年 Peroxisome proliferator-activated receptor alpha as a ...
BBB blood brain barrier GFAP glial fibrillary acidic protein HRP/DAB horseradish peroxidase/3-3-diaminobenzidine chromogen solution DAPI 4′,6-diamidino-2-phenylindole AD Alzheimer’s disease Keywords Hyperammonemia Mitochondria Bioenergetics Biogenesis Oxidative phosphorylation And astroglia ...
This review describes human diseases in which mutations in the components of the core NF-B signaling pathway have been implicated and discusses the molecular mechanisms by which these alterations in NF-B signaling are likely to contribute to the disease pathology. These mutations can be germline or...
PROBLEM TO BE SOLVED: To obtain a novel useful NF-κB activation inhibitor and a composition which is useful for ameliorating various disease symptoms such as inflammation and preventing or improving symptoms associated with physiological aging or photoaging of the skin.OKAMOTO TAKASHI...